about
Structural and molecular evolutionary analysis of Agouti and Agouti-related proteinsA -defensin mutation causes black coat color in domestic dogsMelanocortin 1 Receptor: Structure, Function, and RegulationLoop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and AntagonismThe Melanocortin Receptor System: A Target for Multiple Degenerative DiseasesDevelopment of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.Knottin cyclization: impact on structure and dynamics.More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology.Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).How the leopard hides its spots: ASIP mutations and melanism in wild cats.Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptorsGenetics of Sex-linked yellow in the Syrian hamsterEngineering agatoxin, a cystine-knot peptide from spider venom, as a molecular probe for in vivo tumor imagingThe serine protease Corin is a novel modifier of the Agouti pathway.Melanocortin MC₁ receptor in human genetics and model systems.Transcriptome sequencing reveals differences between primary and secondary hair follicle-derived dermal papilla cells of the Cashmere goat (Capra hircus).Recurrent evolution of melanism in South American felids.A missense mutation in the agouti signaling protein gene (ASIP) is associated with the no light points coat phenotype in donkeysTargeting protein-trafficking pathways alters melanoma treatment sensitivity.Agouti-related protein segments outside of the receptor binding core are required for enhanced short- and long-term feeding stimulationGenome Wide Association Study Identifies New Loci Associated with Undesired Coat Color Phenotypes in Saanen Goats.Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin SystemChemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein.An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells.Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse.New ligands for melanocortin receptors.Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective.Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands.Chemical synthesis, backbone cyclization and oxidative folding of cystine-knot peptides: promising scaffolds for applications in drug design.A workflow for in silico design of hIL-10 and ebvIL-10 inhibitors using well-known miniprotein scaffolds.Identification of single nucleotide polymorphisms in the agouti signaling protein (ASIP) gene in some goat breeds in tropical and temperate climates.Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.Molecular cloning and in silico characterization of knottin peptide, U2-SCRTX-Lit2, from brown spider (Loxosceles intermedia) venom glands.Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3.Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists.Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway.Agouti signalling protein is an inverse agonist to the wildtype and agonist to the melanic variant of the melanocortin-1 receptor in the grey squirrel (Sciurus carolinensis).Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacolog
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structures of the agouti signaling protein
@ast
Structures of the agouti signaling protein
@en
Structures of the agouti signaling protein
@nl
type
label
Structures of the agouti signaling protein
@ast
Structures of the agouti signaling protein
@en
Structures of the agouti signaling protein
@nl
prefLabel
Structures of the agouti signaling protein
@ast
Structures of the agouti signaling protein
@en
Structures of the agouti signaling protein
@nl
P2093
P3181
P1476
Structures of the agouti signaling protein
@en
P2093
Biaoxin Chai
Darren A Thompson
Glenn L Millhauser
Gregory S Barsh
Joseph C McNulty
Philip E Dawson
Pilgrim J Jackson
P304
P3181
P356
10.1016/J.JMB.2004.12.030
P407
P577
2005-03-04T00:00:00Z