Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors - Wikidata - awgldk - TriplyDB

Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors

Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors

http://www.wikidata.org/entity/Q28344116

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International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.Development of selective agonists and antagonists of P2Y receptors.Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.Pharmacochemistry of the platelet purinergic receptors.Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.Agonists and antagonists for P2 receptors.[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.Synthesis of a novel conformationally locked carbocyclic nucleoside ring system.Shift in purine/pyrimidine base recognition upon exchanging extracellular domains in P2Y 1/6 chimeric receptors.Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors.John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors Molecular recognition at adenine nucleotide (P2) receptors in platelets.Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety.Methanocarba ring as a ribose modification in ligands of G protein-coupled purine and pyrimidine receptors: synthetic approaches.Northern Ring Conformation of Methanocarba-Adenosine 5'-Triphosphate Required for Activation of P2X Receptors.Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor (N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.Purine receptors: GPCR structure and agonist design Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation.Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors.Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists Anti-photoaging properties of the phosphodiesterase 3 inhibitor cilostazol in ultraviolet B-irradiated hairless mice Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands.Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose A critical look at the function of the P2Y11 receptor.Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysis.Opposite diastereoselective activation of P2Y1 and P2Y11 nucleotide receptors by adenosine 5'-O-(alpha-boranotriphosphate) analogues.2-Chloro-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist: commentary on Boyer et al.Synthesis of ethyl (1S,2R,3S,4S,5S)-2,3-O-(isopropylidene)-4-hydroxy-bicyclo[3.1.0]hexane-carboxylate from L-ribose: a versatile chiral synthon for preparation of adenosine and P2 receptor ligands.

P2860

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P2860

Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors

http://www.wikidata.org/entity/Q28344116

description

2002 nî lūn-bûn

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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2002 թվականի հունվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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Methanocarba modification of u ...... d P2Y11 but not P2Y6 receptors

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P2093

Anna-Karin Wihlborg

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David Erlinge

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Hak Sung Kim

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José L Boyer

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Kenneth A Jacobson

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R Gnana Ravi

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Savitri Maddileti

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T Kendall Harden

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Victor E Marquez

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P2860

Identification of the platelet ADP receptor targeted by antithrombotic drugs

Cloning and tissue distribution of the human P2Y1 receptor

Human P2Y2 receptor polymorphism: identification and pharmacological characterization of two allelic variants

Pharmacological characterization of the human P2Y11 receptor

Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications

ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor

Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate

Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder

Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor

Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model.

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10.1021/JM010369E

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1

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