Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
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Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysisMolecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.Development of selective agonists and antagonists of P2Y receptors.Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach.Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors.P2Y nucleotide receptors: promise of therapeutic applicationsPyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modificationsModeling G Protein-Coupled Receptors: a Concrete PossibilityDocking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models.Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor.Agonists and antagonists for P2 receptors.Comparison of three GPCR structural templates for modeling of the P2Y12 nucleotide receptor.Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors.Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety.Novel Scaffold Identification of mGlu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach.4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor.G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactionsMolecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptorStructure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptorMolecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes.Probing GPCR structure: adenosine and P2Y nucleotide receptors.Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors.Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.Thymidine 5'-O-monophosphorothioate induces HeLa cell migration by activation of the P2Y6 receptor.Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands.Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator.Synthesis of novel bicyclic nucleosides with 3,6-anhydro sugar moiety.Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y6 Receptor Agonists.
P2860
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P2860
Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Human P2Y(6) receptor: molecul ...... que conformational preference.
@en
type
label
Human P2Y(6) receptor: molecul ...... que conformational preference.
@en
prefLabel
Human P2Y(6) receptor: molecul ...... que conformational preference.
@en
P2093
P2860
P356
P1476
Human P2Y(6) receptor: molecul ...... ique conformational preference
@en
P2093
Bhalchandra V Joshi
Liaman Mamedova
Maria J Gonzalez-Moa
Savitri Maddileti
T Kendall Harden
Victor E Marquez
P2860
P304
P356
10.1021/JM050911P
P407
P577
2005-12-01T00:00:00Z