The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.
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Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitisBioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues.The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes.Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomesA stereochemical investigation of the cytotoxicity of mianserin metabolites in vitro.Comparative effects of two antimycotic agents, ketoconazole and terbinafine on the metabolism of tolbutamide, ethinyloestradiol, cyclosporin and ethoxycoumarin by human liver microsomes in vitro.Calcium channel antagonists and cyclosporine metabolism: in vitro studies with human liver microsomes.Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes.In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolinesAn in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin.Tolbutamide 4-hydroxylase activity of human liver microsomes: effect of inhibitorsOral contraception does not alter single dose saquinavir pharmacokinetics in womenEffects of cytochrome P450 inducers on 17alpha-ethinyloestradiol (EE2) conjugation by primary human hepatocytesPharmacokinetic drug interactions involving 17alpha-ethinylestradiol: a new look at an old drug.R(+)XK469 inhibits hydroxylation of S-warfarin by CYP2C9.Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751.Drug-protein conjugation and its immunological consequences.In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.Studies on the toxicity of analogues of dapsone in-vitro using rat, human and heterologously expressed metabolizing systems.Chronic effects of 17α-ethinylestradiol, fluoxetine, and the mixture on individual and population-level end points in Daphnia magna.Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 alpha-ethinyloestradiol. Relative activities of rat and human liver enzymes.The use of a three compartment in vitro model to investigate the role of hepatic drug metabolism in drug-induced blood dyscrasias.An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system.The effect of preincubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes.Direct and metabolism-dependent toxicity of sulphasalazine and its principal metabolites towards human erythrocytes and leucocytes.Structural requirements for bioactivation of anticonvulsants to cytotoxic metabolites in vitro.Metabolism of ciamexon by human liver microsomes: an investigation into the formation of stable, chemically reactive and cytotoxic metabolites.Gonadal influence on the metabolism and haematological toxicity of dapsone in the rat.Sex hormonal preparations and the liver.Impact of combined oral contraceptives containing ethinylestradiol on the liver microsomal metabolism.Metabolism-guided drug design
P2860
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P2860
The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.
description
1987 nî lūn-bûn
@nan
1987 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
The metabolism of 17 alpha-eth ...... hemically reactive metabolites
@nl
The metabolism of 17 alpha-eth ...... emically reactive metabolites.
@ast
The metabolism of 17 alpha-eth ...... emically reactive metabolites.
@en
type
label
The metabolism of 17 alpha-eth ...... hemically reactive metabolites
@nl
The metabolism of 17 alpha-eth ...... emically reactive metabolites.
@ast
The metabolism of 17 alpha-eth ...... emically reactive metabolites.
@en
prefLabel
The metabolism of 17 alpha-eth ...... hemically reactive metabolites
@nl
The metabolism of 17 alpha-eth ...... emically reactive metabolites.
@ast
The metabolism of 17 alpha-eth ...... emically reactive metabolites.
@en
P2093
P2860
P1476
The metabolism of 17 alpha-eth ...... emically reactive metabolites.
@en
P2093
P2860
P304
P356
10.1111/J.1365-2125.1987.TB03074.X
P407
P577
1987-04-01T00:00:00Z