Effects of antagonists at the human recombinant P2X7 receptor
about
Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesiaModulation of mouse embryonic stem cell proliferation and neural differentiation by the P2X7 receptorFunctional evidence of distinct ATP activation sites at the human P2X(7) receptorInhibition of neuronal cell death after retinoic acid-induced down-regulation of P2X7 nucleotide receptor expression.Activation and regulation of purinergic P2X receptor channelsPiccolo regulates the dynamic assembly of presynaptic F-actinThe impact of commercially available purinergic ligands on purinergic signalling research.P2 receptor subtypes in the cardiovascular system.P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling.Mouse Leydig cells express multiple P2X receptor subunits.Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation.Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain.ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor.Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.Mechanism of action of species-selective P2X(7) receptor antagonists.Atypical P2X receptor pharmacology in two human osteoblast-like cell lines.Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effectsCharacterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.The human SH-SY5Y neuroblastoma cell-line expresses a functional P2X7 purinoceptor that modulates voltage-dependent Ca2+ channel function.Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1.Functional characterization of the P2X(4) receptor orthologuesPharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes.Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding.Identification of Thr283 as a key determinant of P2X7 receptor function.The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro.Spontaneous oscillations in intracellular Ca(2+) concentration via purinergic receptors elicit transient cell swelling in rat parotid ducts.Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.Functional expression of purinergic P2X7 receptors in pregnant rat myometrium.Stimulation of Ca(2+) influx through ATP receptors on rat brain synaptosomes: identification of functional P2X(7) receptor subtypes.Structure-function relationships of AE2 regulation by Ca(i)(2+)-sensitive stimulators NH(4+) and hypertonicity.Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells."Host tissue damage" signal ATP promotes non-directional migration and negatively regulates toll-like receptor signaling in human monocytes.Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation.Characterization of sheep brain ryanodine receptor ATP binding site by photoaffinity labeling.The P2X7receptor as a therapeutic target
P2860
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P2860
Effects of antagonists at the human recombinant P2X7 receptor
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Effects of antagonists at the human recombinant P2X7 receptor
@ast
Effects of antagonists at the human recombinant P2X7 receptor
@en
Effects of antagonists at the human recombinant P2X7 receptor
@nl
type
label
Effects of antagonists at the human recombinant P2X7 receptor
@ast
Effects of antagonists at the human recombinant P2X7 receptor
@en
Effects of antagonists at the human recombinant P2X7 receptor
@nl
prefLabel
Effects of antagonists at the human recombinant P2X7 receptor
@ast
Effects of antagonists at the human recombinant P2X7 receptor
@en
Effects of antagonists at the human recombinant P2X7 receptor
@nl
P2093
P356
P1476
Effects of antagonists at the human recombinant P2X7 receptor
@en
P2093
A D Michel
I P Chessell
P P Humphrey
P2860
P304
P356
10.1038/SJ.BJP.0701958
P407
P577
1998-07-01T00:00:00Z