DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
about
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsMouse Genetic Models of Human Brain DisordersEmerging roles for intersectin (ITSN) in regulating signaling and disease pathwaysMissense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in miceDISC1 at 10: connecting psychiatric genetics and neuroscienceDISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial traffickingAdult neurogenesis and mental illness.Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.DISC1 knockdown impairs the tangential migration of cortical interneurons by affecting the actin cytoskeletonA Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.The crystal structure of human Rogdi provides insight into the causes of Kohlschutter-Tönz SyndromeDisrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses.Disc1 variation leads to specific alterations in adult neurogenesis.Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathiesA t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex.Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.Decoding neuroproteomics: integrating the genome, translatome and functional anatomyDISC1 genetics, biology and psychiatric illnessDISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample.Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia.Altered Disrupted-in-Schizophrenia-1 Function Affects the Development of Cortical Parvalbumin Interneurons by an Indirect Mechanism.NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review.DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders.Neural stem cells: mechanisms and modeling.Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia.Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders.Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches.New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.Disrupted in schizophrenia 1 (DISC1) is a constituent of the mammalian mitochondrial contact site and cristae organizing system (MICOS) complex, and is essential for oxidative phosphorylation.Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine.Interaction of DISC1 with the PTB domain of Tensin2.DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.Neurodegeneration and Cancer: Where the Disorder Prevails.PSD95: A synaptic protein implicated in schizophrenia or autism?A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.Additive sex-specific influence of common non-synonymous DISC1 variants on amygdala, basal ganglia, and white cortical surface area in healthy young adults.
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P2860
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
description
2011 nî lūn-bûn
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2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@ast
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@en
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@nl
type
label
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@ast
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@en
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@nl
prefLabel
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@ast
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@en
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@nl
P2860
P50
P3181
P356
P1476
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
@en
P2860
P304
P3181
P356
10.1021/CN200062K
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P577
2011-11-16T00:00:00Z