A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration - Wikidata - awgldk - TriplyDB

A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration

A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration

http://www.wikidata.org/entity/Q28474016

about

KRIT1 regulates the homeostasis of intracellular reactive oxygen species The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis Multiple phenotypes in Huntington disease mouse neural stem cells.IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.Differential behaviour of normal, transformed and Fanconi's anemia lymphoblastoid cells to modeled microgravity.Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1.Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.Moieties in antidiabetic drugs as a target of insulin receptors in association with common neurological disorders.Markers of oxidant stress that are clinically relevant in aging and age-related disease Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.DNA repair mechanisms in Huntington's disease.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?hMTH1 expression protects mitochondria from Huntington's disease-like impairment.The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders.Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.Detecting reactive oxygen species by immunohistochemistry.

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A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration

http://www.wikidata.org/entity/Q28474016

description

2008 nî lūn-bûn

@nan

2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

A role for oxidized DNA precur ...... ike striatal neurodegeneration

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A role for oxidized DNA precur ...... ike striatal neurodegeneration

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A role for oxidized DNA precur ...... ike striatal neurodegeneration

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type

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A role for oxidized DNA precur ...... ike striatal neurodegeneration

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A role for oxidized DNA precur ...... ike striatal neurodegeneration

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A role for oxidized DNA precur ...... ike striatal neurodegeneration

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prefLabel

A role for oxidized DNA precur ...... ike striatal neurodegeneration

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A role for oxidized DNA precur ...... ike striatal neurodegeneration

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A role for oxidized DNA precur ...... ike striatal neurodegeneration

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JOURNAL.PGEN.1000266

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A role for oxidized DNA precur ...... ike striatal neurodegeneration

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Antonella Pèzzola

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Cecilia Tiveron

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Elisabetta Mattei

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Ilenia Ventura

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Margherita Bignami

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Maria Teresa Russo

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Paolo Degan

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Patrizia Popoli

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Rita Pepponi

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P2860

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

The role of CSA in the response to oxidative DNA damage in human cells

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria

A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

Paraquat: model for oxidant-initiated toxicity

Mammalian enzymes for preventing transcriptional errors caused by oxidative damage.

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Defective DNA repair and neurodegenerative disease

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e1000266

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scholarly article

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10.1371/JOURNAL.PGEN.1000266

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11

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4

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Marco Crescenzi

Yusaku Nakabeppu

Gabriele De Luca

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2008-11-21T00:00:00Z

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23487396

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19023407

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corpus striatum

Huntington disease

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2580033

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