IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.

IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.

Item
http://www.wikidata.org/entity/Q33458331
Defining the role of the Bcl-2 family proteins in Huntington's diseaseA genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's diseaseIKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging.Elevated IKKα accelerates the differentiation of human neuronal progenitor cells and induces MeCP2-dependent BDNF expression.Does Huntingtin play a role in selective macroautophagy?The role of IκB kinase complex in the neurobiology of Huntington's disease.Epigenetic treatment of neurological disease.Targeting Huntington's disease through histone deacetylases.NF-κB signaling pathways: role in nervous system physiology and pathology.The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach.Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications.Regulation of Survival Motor Neuron Protein by the Nuclear Factor-Kappa B Pathway in Mouse Spinal Cord Motoneurons.Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of BaxIKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE).
P2860

IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.

Item
http://www.wikidata.org/entity/Q33458331
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
@ast
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
@en
type
label
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
@ast
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
@en
prefLabel
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
@ast
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
@en
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IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
@en
P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0005768
P407
P433
P478
P577
P5875
P698
P921
P932