Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent
about
Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancerHypermutation in human cancer genomes: footprints and mechanismsGenome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminaseIs homologous recombination really an error-free process?Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitnessThe 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo1.DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegisThe oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cellsBreak-induced replication is a source of mutation clusters underlying kataegisBRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancersMechanisms of glycosylase induced genomic instabilityClusters of Multiple Mutations: Incidence and Molecular MechanismsRecombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection.Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli.APOBEC3A damages the cellular genome during DNA replicationRole of the double-strand break repair pathway in the maintenance of genomic stability.Mutation at a distance caused by homopolymeric guanine repeats in Saccharomyces cerevisiaeAn APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines.The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis.CpG dinucleotide frequencies reveal the role of host methylation capabilities in parvovirus evolution.APOBEC3B gene overexpression in non-small-cell lung cancer.Functions and Malfunctions of Mammalian DNA-Cytosine DeaminasesPreventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells.Molecular Genetic Characterization of Mutagenesis Using a Highly Sensitive Single-Stranded DNA Reporter System in Budding Yeast.
P2860
Q28088790-28369686-5DAC-4EC3-88B7-1167F0C80021Q28255066-71D2EA04-6D8E-4C15-8E61-2BD742A2990AQ28536837-23EE8601-0B46-4FC2-B6DF-10071C21E67BQ33736829-CF9DD6B4-B282-4AE1-B124-B5E81D6CBA68Q34090613-155EE83A-6877-40CA-AF46-ECB9FD64ECF1Q34249598-D17BD75B-7933-448A-A4E5-898A3EBB71DDQ34340260-50E93EE5-FD85-4298-9840-AF9E91706976Q34487363-7125C6EB-E1AC-4F7C-A7BB-683B577785FCQ34757099-838EA86F-956B-41D4-B778-BFB63D083EA1Q35153726-B5570A3B-CF21-45C3-85B8-2C7394011EEAQ36123927-7E6F5525-BE33-4FE9-A9F0-76ACCBB492A2Q36319705-2B160553-6EC3-49B3-A59A-E8D52BA8940CQ36455998-8437F2D6-2394-4C34-86D0-5842E04A228AQ36532628-0A58906B-ED8E-4156-ABA5-86B58ECD9DC3Q36646366-47A28B6C-4A48-48B1-9CFC-FCC7B78AE76CQ36956935-150CFDA4-0C68-4B74-927E-F3473D671216Q36997781-0AD9DA0A-6FB3-44E3-97BE-CE17EDDD4656Q37056244-C9C5C7AC-5AFE-4BC5-A791-B9CE96A56294Q37211712-FB16C014-33DE-40AE-B8C9-29BE163AC255Q37236755-FAEFC990-8EAD-4168-ABB7-02E9E5E4D6F5Q37302944-C2825AF0-4A00-4679-8C1D-8FDDD77E269CQ37336773-E1E00DF2-C3F6-4558-ACA2-92991FFF2EEEQ37708487-4278838F-42DB-4A32-BB8A-66FBD05153A9Q38943944-14802143-637C-494E-9CC1-4303E8E12811Q39015856-C6B91E59-DD66-4615-8FA7-5C2E56A52F40Q46281976-648C8C29-D967-48E5-B571-5FF214BFB133
P2860
Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
name
Base damage within single-stra ...... ubiquitous environmental agent
@ast
Base damage within single-stra ...... ubiquitous environmental agent
@en
Base damage within single-stra ...... ubiquitous environmental agent
@nl
type
label
Base damage within single-stra ...... ubiquitous environmental agent
@ast
Base damage within single-stra ...... ubiquitous environmental agent
@en
Base damage within single-stra ...... ubiquitous environmental agent
@nl
prefLabel
Base damage within single-stra ...... ubiquitous environmental agent
@ast
Base damage within single-stra ...... ubiquitous environmental agent
@en
Base damage within single-stra ...... ubiquitous environmental agent
@nl
P2093
P2860
P50
P3181
P1433
P1476
Base damage within single-stra ...... ubiquitous environmental agent
@en
P2093
Ashok S Bhagwat
Joan F Sterling
Steven A Roberts
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1003149
P407
P577
2012-12-13T00:00:00Z