Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes
about
The glucose-6-phosphatase systemG6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunctionFoxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expressionA syndrome with congenital neutropenia and mutations in G6PC3Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.Glycogen metabolism in humansHistidine 167 is the phosphate acceptor in glucose-6-phosphatase-beta forming a phosphohistidine enzyme intermediate during catalysisGlucose-6-phosphatase catalytic subunit gene familyMembers of the large Maf transcription family regulate insulin gene transcription in islet beta cellsIdentification and characterisation of a new human glucose-6-phosphatase isoformHomozygosity mapping and whole-exome sequencing to detect SLC45A2 and G6PC3 mutations in a single patient with oculocutaneous albinism and neutropeniaMoving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane.Large scale meta-analyses of fasting plasma glucose raising variants in GCK, GCKR, MTNR1B and G6PC2 and their impacts on type 2 diabetes mellitus risk.A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetesNovel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets.Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice.Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection.G6PC2: a negative regulator of basal glucose-stimulated insulin secretionInborn errors of metabolism underlying primary immunodeficiencies.Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1.G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance.Effects of G6pc2 deletion on body weight and cholesterol in mice.Role of TGF-β in Self-Peptide Regulation of Autoimmunity.Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide.Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related protein (IGRP) gene expression.Cytokine-induced dicing and splicing in the beta-cell and the immune response in type 1 diabetes.Endoplasmic reticulum stress caused by overexpression of islet-specific glucose-6-phosphatase catalytic subunit-related protein in pancreatic Beta-cells.The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression.The CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development.A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.IC-Tagging methodology applied to the expression of viral glycoproteins and the difficult-to-express membrane-bound IGRP autoantigen
P2860
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P2860
Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes
description
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im Juli 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/07/06)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/07/06)
@nl
наукова стаття, опублікована в липні 2001
@uk
name
Cloning and characterization o ...... t-related protein (IGRP) genes
@ast
Cloning and characterization o ...... t-related protein (IGRP) genes
@en
Cloning and characterization o ...... t-related protein (IGRP) genes
@nl
type
label
Cloning and characterization o ...... t-related protein (IGRP) genes
@ast
Cloning and characterization o ...... t-related protein (IGRP) genes
@en
Cloning and characterization o ...... t-related protein (IGRP) genes
@nl
prefLabel
Cloning and characterization o ...... t-related protein (IGRP) genes
@ast
Cloning and characterization o ...... t-related protein (IGRP) genes
@en
Cloning and characterization o ...... t-related protein (IGRP) genes
@nl
P2093
P2860
P3181
P356
P1476
Cloning and characterization o ...... t-related protein (IGRP) genes
@en
P2093
B. Bergman
C. A. Svitek
C. C. Martin
C. Frigeri
C. Hilliker
F. Leprêtre
J. C. Hutton
J. K. Goldman
J. K. Oeser
P2860
P304
25197–25207
P3181
P356
10.1074/JBC.M101549200
P407
P577
2001-07-06T00:00:00Z