Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction
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Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycleDown-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neuronsCharcot-Marie-Tooth disease and intracellular trafficInduction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISCRab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo.Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4Novel functions of Stomatal Cytokinesis-Defective 1 (SCD1) in innate immune responses against bacteria.A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria.Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans.Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.Small G proteins as key regulators of pancreatic digestive enzyme secretion.Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.Proteomics of regulated secretory organelles.IG20/MADD plays a critical role in glucose-induced insulin secretion.DENN domain proteins: regulators of Rab GTPases.Rab27 effectors, pleiotropic regulators in secretory pathways.GTP binds to Rab3A in a complex with Ca2+/calmodulin.Building a Terminal: Mechanisms of Presynaptic Development in the CNS.DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini.Dominant negative Rab3D mutants reduce GTP-bound endogenous Rab3D in pancreatic acini.Effect of inherited abnormalities of calcium regulation on human neuromuscular transmission.Expanding the genetic heterogeneity of intellectual disability.Synaptotagmin-1 promotes the formation of axonal filopodia and branches along the developing axons of forebrain neurons.Subcellular localization of neural-specific NPDC-1 protein.MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7.New approaches for solving old problems in neuronal protein trafficking.
P2860
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P2860
Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction
description
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Mai 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/05/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/05/01)
@nl
наукова стаття, опублікована в травні 2001
@uk
مقالة علمية (نشرت في مايو 2001)
@ar
name
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@ast
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@en
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@nl
type
label
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@ast
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@en
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@nl
prefLabel
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@ast
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@en
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@nl
P2093
P2860
P356
P1476
Role of Rab3 GDP/GTP exchange ...... e mouse neuromuscular junction
@en
P2093
A. Mizoguchi
H. Ishizaki
J. Miyoshi
K. Matsubara
K. Ohnishi
P2860
P304
P356
10.1091/MBC.12.5.1421
P577
2001-05-01T00:00:00Z