Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
about
Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitusDifferent role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitusThe Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and PerspectiveZinc and diabetes mellitus: understanding molecular mechanisms and clinical implicationsZinc transporter 8 (ZnT8) and β cell functionThe physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic backgroundZinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantationZinc transporters and zinc signaling: new insights into their role in type 2 diabetesBridging the gap between genetic associations and molecular mechanisms for type 2 diabetes.Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearanceComparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose ChallengeThe influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function.Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application.The MafA transcription factor becomes essential to islet β-cells soon after birth.Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and NickelLoss-of-function mutations in SLC30A8 protect against type 2 diabetesDetailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes.The pancreatic β cell: recent insights from human genetics.Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cellsZinc transporter expression in zebrafish (Danio rerio) during development.Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish.Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.Islet autoantigens: structure, function, localization, and regulation.Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance.Zinc transporters, mechanisms of action and therapeutic utility: implications for type 2 diabetes mellitus.Functional role of intracellular labile zinc in pulmonary endothelium.Imaging trace element distributions in single organelles and subcellular featuresThe new perspectives on genetic studies of type 2 diabetes and thyroid diseasesInteractions between genetic background, insulin resistance and β-cell function.Animal models of GWAS-identified type 2 diabetes genes.Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets.Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.Quantitative measurement of zinc secretion from pancreatic islets with high temporal resolution using droplet-based microfluidics.Analysis of Zinc-Exporters Expression in Prostate Cancer.Lack of Association between SLC30A8 Variants and Type 2 Diabetes in Mexican American Families.
P2860
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P2860
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
description
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Juli 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/07/15)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/07/15)
@nl
наукова стаття, опублікована в липні 2009
@uk
مقالة علمية (نشرت في 15-7-2009)
@ar
name
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@ast
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@en
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@nl
type
label
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@ast
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@en
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@nl
prefLabel
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@ast
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@en
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@nl
P2093
P2860
P3181
P356
P1433
P1476
Deletion of the mouse Slc30a8 ...... in impaired insulin secretion
@en
P2093
Adisak Suwanichkul
Catherine E Lee
David R Powell
David W Piston
James K Oeser
John C Hutton
Lynley D Pound
Melanie K Shadoan
Owen P McGuinness
Richard L Printz
P2860
P304
P3181
P356
10.1042/BJ20090530
P407
P577
2009-07-15T00:00:00Z