Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases
about
Phosphoinositide 3-kinase: friend and foe in cardiovascular diseaseStudying GPCR/cAMP pharmacology from the perspective of cellular structurePhosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotidesTherapeutic potential of PDE modulation in treating heart diseaseTargeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of CardiologyAdvances in targeting cyclic nucleotide phosphodiesterasesCyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms.Clinical and molecular genetics of the phosphodiesterases (PDEs).Therapeutic applications of PI3K inhibitors in cardiovascular diseases.Biophysical techniques for detection of cAMP and cGMP in living cells.Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation.Myocyte signalling in leucocyte recruitment to the heart.Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis.Scaffolding Function of PI3Kgamma Emerges from Enzyme's Shadow.Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling.Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts.Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction.Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes.Functions of PDE3 Isoforms in Cardiac Muscle.
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P2860
Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases
description
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2012
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im Oktober 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2012/10/23)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/10/23)
@nl
наукова стаття, опублікована в жовтні 2012
@uk
مقالة علمية (نشرت في 23-10-2012)
@ar
name
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@ast
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@en
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@nl
type
label
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@ast
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@en
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@nl
prefLabel
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@ast
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@en
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@nl
P2093
P2860
P50
P921
P1433
P1476
Phosphoinositide 3-kinase γ pr ...... of distinct phosphodiesterases
@en
P2093
Alessia Perino
Ana Maria Gomez
Elisa De Luca
Federico Damilano
Hind Mehel
James Cimino
Marco Conti
Ruth Westenbroek
P2860
P304
P356
10.1161/CIRCULATIONAHA.112.114074
P407
P50
P577
2012-09-24T00:00:00Z