about
Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potentialPhosphoinositide 3-kinase: friend and foe in cardiovascular diseaseNADPH oxidases in heart failure: poachers or gamekeepers?Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterasesLack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.Data demonstrating the anti-oxidant role of hemopexin in the heart.Anchoring proteins as regulators of signaling pathways.Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterasesTaming the PI3K team to hold inflammation and cancer at bay.PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.Phosphoinositides and cardiovascular diseases.PI3K in cancer-stroma interactions: bad in seed and ugly in soil.Myocyte signalling in leucocyte recruitment to the heart.Crossroads of PI3K and Rac pathways.Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension.Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.New signal transduction paradigms in anthracycline-induced cardiotoxicity.Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.Models of Heart Failure Based on the Cardiotoxicity of Anticancer Drugs.Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).Pi3ks In Diabetic Cardiomyopathy.PI3K and Calcium Signaling in Cardiovascular Disease.Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis.Rac signal adaptation controls neutrophil mobilization from the bone marrow.Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema.Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth.Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective.Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.PI3K signaling in chronic obstructive pulmonary disease: mechanisms, targets, and therapy.A novel protective role for activating transcription factor 3 in the cardiac response to metabolic stress.
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alessandra Ghigo
@ast
Alessandra Ghigo
@en
Alessandra Ghigo
@es
Alessandra Ghigo
@nl
type
label
Alessandra Ghigo
@ast
Alessandra Ghigo
@en
Alessandra Ghigo
@es
Alessandra Ghigo
@nl
prefLabel
Alessandra Ghigo
@ast
Alessandra Ghigo
@en
Alessandra Ghigo
@es
Alessandra Ghigo
@nl
P106
P21
P2798
P31
P496
0000-0002-1193-5296