about
Juvenile myelomonocytic leukemia: molecular pathogenesis informs current approaches to therapy and hematopoietic cell transplantationA RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressorA murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formationThe interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 miceHyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitroA cytokine-cytokine interaction in the assembly of higher-order structure and activation of the interleukine-3:receptor complex.Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.Increased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro.Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorderTherapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia.Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve.PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant miceK-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cellsHuman somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells.Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice.IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease.Quantitative effects of Nf1 inactivation on in vivo hematopoiesisTargeting oncogenic Ras signaling in hematologic malignancies.Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.A coordinated change in chemokine responsiveness guides plasma cell movementsGranulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cellsRegulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype.Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.Neurofibromin regulates somatic growth through the hypothalamic-pituitary axisHigh-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesisJuvenile myelomonocytic leukemia and chronic myelomonocytic leukemia.Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium.The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.Multiple roles of NF1 in the melanocyte lineage.The role of the immune system in neurofibromatosis type 1-associated nervous system tumors.Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
P2860
Q26851000-31016805-AA74-482A-9364-242C684C149BQ27003534-20E83F4C-EB46-4DBF-8C72-525317391503Q27301307-777D7D3F-59E4-4C79-AB5F-D784442130B6Q28282456-F10F6456-9749-4E2C-AF53-3E62DD3F17CBQ28513847-3A0C6A1E-859E-4C6A-8D79-0BC583115060Q28594862-A9E5476A-DB73-4C25-AF35-BFB1A041E612Q33427864-627A73FC-9460-46EF-ADDF-323DE952254FQ33774488-4A2D7D7B-DF93-41CF-B67B-A99C90120EADQ34161443-394BA7D5-46F8-4C13-858D-7BFB20B55E81Q34265808-B8727153-67DB-4CEA-997D-141D9D5821E3Q34304678-5A88AA0D-1317-4DC3-8E8A-7E1FD6056822Q34541593-17D9A0CF-B6F3-416D-8A86-9641FE59E9CBQ34722748-0BC38942-392C-4F86-A24E-548262E1ABD4Q35186888-0B3536EF-98E0-4E01-9BE7-A8DDC842844CQ35237519-9C2A24E6-ADCD-407A-8AED-1ADCD372BE47Q35538007-2E8D67CC-E3FE-44FD-80D7-71F76801F7A2Q35616065-D617D451-E2A4-4624-AA82-0C3FA8639992Q35628894-31432D6B-98B5-4234-9B28-B4657695AA14Q35804477-6C947330-C0FC-450A-B571-3366A33624F0Q35847470-2996D7BD-BC61-446A-8DA3-C3BF8DC65E72Q35847802-A36674D3-5A77-46EC-8209-CAF90D5587E9Q35905350-7725F26C-245A-45F8-AD0C-CDE07969DEAEQ36161397-41CA7358-9DBC-402D-97A0-02A1DFC8BC06Q36167910-BDB5E5AE-E3C1-43B6-8762-E0CB9C0B790DQ36352506-81684554-F1A3-4F9F-8C53-EDB1AB916C10Q36366410-462A94A5-0B10-4B8F-9D8B-76DA590F17E9Q36369352-EFD7C206-11A4-4750-81CD-674F55C761BDQ36403358-1F463CA0-623E-4CC1-BF8E-1A28A52B5A4DQ36407371-12ED686C-0018-4A92-A132-25F7C057D8A8Q36422351-3B63BF3B-A609-4509-92C2-C6D513444035Q36468302-CADA66AC-F0AD-4DEC-92DA-FBA96518DCC3Q37001127-951DE80B-868F-4131-A70A-F65374EFE4FAQ37109358-7D0A8BE6-B477-4400-90FE-2173E912DAA3Q37176577-39E1A706-315C-4AF5-95D0-1FF94DDD70ABQ37189322-A17126E9-5F8A-42D1-9808-869D9DE92179Q37218206-67B0FC82-EAD9-4D9E-9CAF-28464EFD4655Q37306641-4A8C958F-E3B3-4B7D-901D-882CB122C6FDQ38828126-4A090BA4-2D5B-405E-829F-07654950F92AQ39045958-C6DDE8EC-484C-4A3A-9DD7-A9EF09AF218AQ40039203-93BA7BBC-3C8B-4C7D-B689-A03B9734DC7C
P2860
description
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artikull shkencor
@sq
artículu científicu espublizáu en 2000
@ast
im Januar 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2000
@uk
مقالة علمية (نشرت عام 2000)
@ar
name
Nf1 and Gmcsf interact in myeloid leukemogenesis
@ast
Nf1 and Gmcsf interact in myeloid leukemogenesis
@en
Nf1 and Gmcsf interact in myeloid leukemogenesis
@nl
type
label
Nf1 and Gmcsf interact in myeloid leukemogenesis
@ast
Nf1 and Gmcsf interact in myeloid leukemogenesis
@en
Nf1 and Gmcsf interact in myeloid leukemogenesis
@nl
prefLabel
Nf1 and Gmcsf interact in myeloid leukemogenesis
@ast
Nf1 and Gmcsf interact in myeloid leukemogenesis
@en
Nf1 and Gmcsf interact in myeloid leukemogenesis
@nl
P2093
P1433
P1476
Nf1 and Gmcsf interact in myeloid leukemogenesis
@en
P2093
K M Shannon
R A Birnbaum
P304
P356
10.1016/S1097-2765(00)80415-3
P577
2000-01-01T00:00:00Z