Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. - Wikidata - awgldk - TriplyDB

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.

http://www.wikidata.org/entity/Q36366410

about

A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus Cancer stem cell-like cells derived from malignant peripheral nerve sheath tumors.MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.Cancer stem cells: a stride towards cancer cure?In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1.Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors.Neurofibromin deficiency-associated transcriptional dysregulation suggests a novel therapy for tibial pseudoarthrosis in NF1.Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene Runx1 contributes to neurofibromatosis type 1 neurofibroma formation.Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2.The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development.Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop.Genomic amplification and high expression of EGFR are key targetable oncogenic events in malignant peripheral nerve sheath tumor.An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.EGFR-Stat3 signalling in nerve glial cells modifies neurofibroma initiation.The role of stem cells in benign tumors.Back to the future: proceedings from the 2010 NF Conference.What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers

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P2860

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.

http://www.wikidata.org/entity/Q36366410

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

@zh-sg

2008年學術文章

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2008年學術文章

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2008年學術文章

@zh-hant

name

Nf1 mutation expands an EGFR-d ...... fibroma tumorigenic potential.

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Nf1 mutation expands an EGFR-d ...... fibroma tumorigenic potential.

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type

label

Nf1 mutation expands an EGFR-d ...... fibroma tumorigenic potential.

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Nf1 mutation expands an EGFR-d ...... fibroma tumorigenic potential.

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prefLabel

Nf1 mutation expands an EGFR-d ...... fibroma tumorigenic potential.

@ast

Nf1 mutation expands an EGFR-d ...... fibroma tumorigenic potential.

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J.STEM.2008.10.003

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Nf1 mutation expands an EGFR-d ...... ofibroma tumorigenic potential

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Gunnar Johansson

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Hartmut Geiger

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Jianqiang Wu

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Jon P Williams

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Jose A Cancelas

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Nancy Ratner

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Punam Malik

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Shyra C Miller

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Tilat A Rizvi

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Wenling Li

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P2860

Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members

Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis

Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells

NF1 gene and neurofibromatosis 1

EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

Nf1 and Gmcsf interact in myeloid leukemogenesis

Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells

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Yoh-Suke Mukouyama

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