Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation

Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation

Item
http://www.wikidata.org/entity/Q28507194
Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcriptionInduction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-IDNA-binding properties of ARID family proteinsSUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes.Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.Communication routes in ARID domains between distal residues in helix 5 and the DNA-binding loops.The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.Transgenic mice expressing dominant-negative bright exhibit defects in B1 B cells.The Bright Side of Hematopoiesis: Regulatory Roles of ARID3a/Bright in Human and Mouse Hematopoiesis.Human effector B lymphocytes express ARID3a and secrete interferon alpha.The Transcription Factor ARID3a Is Important for In Vitro Differentiation of Human Hematopoietic Progenitors.Bright/Arid3A acts as a barrier to somatic cell reprogramming through direct regulation of Oct4, Sox2, and Nanog.Anti-nuclear antibody production and autoimmunity in transgenic mice that overexpress the transcription factor Bright.Splice variants of the SIP1 transcripts play a role in nodule organogenesis in Lotus japonicus.A novel ARID DNA-binding protein interacts with SymRK and is expressed during early nodule development in Lotus japonicus.REKLES is an ARID3-restricted multifunctional domain.
P2860

Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation

Item
http://www.wikidata.org/entity/Q28507194
description
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im Dezember 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/12/10)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/12/10)
@nl
наукова стаття, опублікована в грудні 2004
@uk
name
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@ast
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@en
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@nl
type
label
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@ast
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@en
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@nl
prefLabel
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@ast
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@en
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Mutations in the DNA-binding d ...... immunoglobulin transactivation
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921