Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium - Wikidata - awgldk - TriplyDB

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

http://www.wikidata.org/entity/Q28507314

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Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?Thin filament mutations: developing an integrative approach to a complex disorder Combinatorial effects of double cardiomyopathy mutant alleles in rodent myocytes: a predictive cellular model of myofilament dysregulation in disease Insights into human beta-cardiac myosin function from single molecule and single cell studies.Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models.Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.Genetic causes of human heart failure.β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations Regulatory light chain phosphorylation and N-terminal extension increase cross-bridge binding and power output in Drosophila at in vivo myofilament lattice spacing Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fraction Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities.Two-state model of acto-myosin attachment-detachment predicts C-process of sinusoidal analysis Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.Zinc-induced cardiomyocyte relaxation in a rat model of hyperglycemia is independent of myosin isoform.Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone Molecular mechanisms underlying skeletal muscle weakness in human cancer: reduced myosin-actin cross-bridge formation and kinetics.Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function.Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice Age-related slowing of myosin actin cross-bridge kinetics is sex specific and predicts decrements in whole skeletal muscle performance in humans.Designing heart performance by gene transfer.Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.How do mutations in contractile proteins cause the primary familial cardiomyopathies?A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.Molecular mechanisms of sarcomere dysfunction in dilated and hypertrophic cardiomyopathy.Erythropoietin induces positive inotropic and lusitropic effects in murine and human myocardium.A strain-dependency of Myosin off-rate must be sensitive to frequency to predict the B-process of sinusoidal analysis.Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levels.An analysis of deformation-dependent electromechanical coupling in the mouse heart.Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs.The genetics of hypertrophic cardiomyopathy

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Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

http://www.wikidata.org/entity/Q28507314

description

2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2004 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2004

@ast

im Juli 2004 veröffentlichter wissenschaftlicher Artikel

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scientific journal article

@en

vedecký článok (publikovaný 2004/07/01)

@sk

vědecký článek publikovaný v roce 2004

@cs

wetenschappelijk artikel (gepubliceerd op 2004/07/01)

@nl

наукова стаття, опублікована в липні 2004

@uk

مقالة علمية (نشرت في يوليو 2004)

@ar

name

Differential cross-bridge kine ...... heterozygous mouse myocardium

@ast

Differential cross-bridge kine ...... heterozygous mouse myocardium

@en

Differential cross-bridge kine ...... heterozygous mouse myocardium

@nl

type

label

Differential cross-bridge kine ...... heterozygous mouse myocardium

@ast

Differential cross-bridge kine ...... heterozygous mouse myocardium

@en

Differential cross-bridge kine ...... heterozygous mouse myocardium

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prefLabel

Differential cross-bridge kine ...... heterozygous mouse myocardium

@ast

Differential cross-bridge kine ...... heterozygous mouse myocardium

@en

Differential cross-bridge kine ...... heterozygous mouse myocardium

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AJPHEART.01015.2003

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American Journal of Physiology - Heart and Circulatory Physiology

P1476

Differential cross-bridge kine ...... heterozygous mouse myocardium

@en

P2093

Bradley M. Palmer

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Christine E. Seidman

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David E. Fishbaugher

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David W. Maughan

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J. G. Seidman

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Joachim P. Schmitt

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Norman R. Alpert

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Peter VanBuren

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Yuan Wang

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P2860

Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy

Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

A mouse model of familial hypertrophic cardiomyopathy

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

The Genetic Basis for Cardiomyopathy

An improved assay for nanomole amounts of inorganic phosphate

The molecular genetic basis for hypertrophic cardiomyopathy.

Variable surface loops and myosin activity: accessories to a motor.

Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy

New concepts in hypertrophic cardiomyopathies, part I.

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10.1152/AJPHEART.01015.2003

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Myosin, heavy polypeptide 6, cardiac muscle, alpha