Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility. - Wikidata - awgldk - TriplyDB

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

http://www.wikidata.org/entity/Q37680390

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Targets for therapy in sarcomeric cardiomyopathies Research priorities in sarcomeric cardiomyopathies Altered Calcium Handling and Ventricular Arrhythmias in Acute Ischemia Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian Descendants Epigallocatechin-3-Gallate Accelerates Relaxation and Ca2+ Transient Decay and Desensitizes Myofilaments in Healthy and Mybpc3-Targeted Knock-in Cardiomyopathic Mice.Cardiac inotropy, lusitropy, and Ca2+ handling with major metabolic substrates in rat heart Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.Single-sensor system for spatially resolved, continuous, and multiparametric optical mapping of cardiac tissue.Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies Insights into restrictive cardiomyopathy from clinical and animal studies.Mechanical and energetic properties of papillary muscle from ACTC E99K transgenic mouse models of hypertrophic cardiomyopathy.Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments.Optical imaging of voltage and calcium in cardiac cells & tissues Proteasome dysfunction in cardiomyopathies.Current insights into LMNA cardiomyopathies: Existing models and missing LINCs Linking myofilaments to sudden cardiac death: recent advances.Raf kinase inhibitor protein: lessons of a better way for β-adrenergic receptor activation in the heart.Myofilament protein dynamics modulate EAD formation in human hypertrophic cardiomyopathy.Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model.Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.Familial hypertrophic cardiomyopathy: is the Frank-Starling law kaput?Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.Age- and strain-related aberrant Ca2+ release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy.Emerging pharmacologic and structural therapies for hypertrophic cardiomyopathy.Neuronal nitric oxide synthase modulation of intracellular Ca2+ handling overrides fatty acid potentiation of cardiac inotropy in hypertensive rats.Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.Calcium in Brugada Syndrome: Questions for Future Research Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits Association of cardiac myosin-binding protein-C with the ryanodine receptor channel - putative retrograde regulation?

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P2860

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

http://www.wikidata.org/entity/Q37680390

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 22 January 2010

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

@en

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

@nl

type

label

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

@en

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

@nl

prefLabel

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

@en

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

@nl

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J.YJMCC.2010.01.011

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Journal of Molecular and Cellular Cardiology

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Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility

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Sabine Huke

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P2860

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

Kir6.2 is required for adaptation to stress.

Hypercontractile properties of cardiac muscle fibers in a knock-in mouse model of cardiac myosin-binding protein-C

Functional consequences of the deletion mutation deltaGlu160 in human cardiac troponin T

Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers

A new mutation of the cardiac troponin T gene causing familial hypertrophic cardiomyopathy without left ventricular hypertrophy

Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy

The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice

ATP-regulated K+ channels in cardiac muscle

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824-833

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scholarly article

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10.1016/J.YJMCC.2010.01.011

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5

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48

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Bjorn C. Knollmann

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2010-01-22T00:00:00Z

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41122594

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20097204

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