Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2
about
Regulation of gene expression in osteoblasts.Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and diseaseHistone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossificationNeuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanismGenetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's diseaseProtein kinase D1 is essential for bone acquisition during pubertal growth.Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signalingA positive role of microRNA-15b on regulation of osteoblast differentiation.PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-κB- and HDAC1-mediated expression and activation of uPAAn integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling.Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.P38 and ERK1/2 MAPKs act in opposition to regulate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity.Histone deacetylases in skeletal development and bone mass maintenance.Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosisProtein kinase D: coupling extracellular stimuli to the regulation of cell physiologyProtein kinase D signaling: multiple biological functions in health and disease.Hdac-mediated control of endochondral and intramembranous ossificationStrategies to minimize hypertrophy in cartilage engineering and regeneration.Protein kinase D promotes in vitro osteoclast differentiation and fusion.PTH Signaling and Epigenetic Control of Bone Remodeling.Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis.A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development.Physiological functions of protein kinase D in vivo.Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease.Dynamic and distinct histone modifications of osteogenic genes during osteogenic differentiation.Melatonin promotes osteoblast differentiation and mineralization of MC3T3-E1 cells under hypoxic conditions through activation of PKD/p38 pathways.Deletion of protein kinase D1 in osteoprogenitor cells results in decreased osteogenesis in vitro and reduced bone mineral density in vivo.Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells.Protein kinase D exerts neuroprotective functions during oxidative stress via nuclear factor kappa B-independent signaling pathways.
P2860
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P2860
Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2
description
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2009
@ast
im Januar 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/01/23)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/01/23)
@nl
наукова стаття, опублікована в січні 2009
@uk
name
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@ast
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@en
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@nl
type
label
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@ast
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@en
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@nl
prefLabel
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@ast
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@en
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@nl
P2093
P2860
P356
P1476
Bone morphogenic protein 2 act ...... zation and repression of Runx2
@en
P2093
Eric D. Jensen
Jennifer J. Westendorf
Rajaram Gopalakrishnan
P2860
P304
P356
10.1074/JBC.M800586200
P407
P577
2009-01-23T00:00:00Z