Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice
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Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitorsThe tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.Familial syndromes associated with neuroendocrine tumoursMenin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4cAltered MENIN expression disrupts the MAFA differentiation pathway in insulinomaMutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cellsConditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissuesMenin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells.Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma.Prognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors.Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in miceReversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.Telomere dysfunction suppresses multiple endocrine neoplasia in mice.Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours.Osteoblast menin regulates bone mass in vivo.Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studiesParathyroid tumor development involves deregulation of homeobox genesMultiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth.Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine TumorsLoss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosisPro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).Animal models of pituitary neoplasiaImmunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studiesActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a β-Cell-Induced DedifferentiationPriorities for improving the management of gastroenteropancreatic neuroendocrine tumors.Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.Menin: a scaffold protein that controls gene expression and cell signaling.Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase.Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease.Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of {beta}-catenin.A MEN1 pancreatic neuroendocrine tumour mouse model under temporal control.Menin Modulates Mammary Epithelial Cell Numbers in Bovine Mammary Glands Through Cyclin D1.The future: genetics advances in MEN1 therapeutic approaches and management strategies.Epigenetic regulation by the menin pathway.Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models.ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
P2860
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P2860
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice
description
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im August 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/08/15)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/08/15)
@nl
наукова стаття, опублікована в серпні 2003
@uk
مقالة علمية (نشرت في 15-8-2003)
@ar
name
Pancreatic beta-cell-specific ...... insulinoma development in mice
@ast
Pancreatic beta-cell-specific ...... insulinoma development in mice
@en
Pancreatic beta-cell-specific ...... insulinoma development in mice
@nl
type
label
Pancreatic beta-cell-specific ...... insulinoma development in mice
@ast
Pancreatic beta-cell-specific ...... insulinoma development in mice
@en
Pancreatic beta-cell-specific ...... insulinoma development in mice
@nl
prefLabel
Pancreatic beta-cell-specific ...... insulinoma development in mice
@ast
Pancreatic beta-cell-specific ...... insulinoma development in mice
@en
Pancreatic beta-cell-specific ...... insulinoma development in mice
@nl
P2093
P1433
P1476
Pancreatic beta-cell-specific ...... insulinoma development in mice
@en
P2093
Chang Xian Zhang
Huguette Casse
Philippe Bertolino
Wei-Min Tong
Zhao-Qi Wang
P304
P407
P577
2003-08-01T00:00:00Z