Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues
about
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversiesBivalent histone modifications in early embryogenesisGrowth hormone-secreting tumors: genetic aspects and data from animal modelsMenin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4cMutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cellsGenetically engineered mouse models of pituitary tumorsMultiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in miceReversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.Telomere dysfunction suppresses multiple endocrine neoplasia in mice.Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency.Osteoblast menin regulates bone mass in vivo.Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studiesMultiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.Proliferation rates of multiple endocrine neoplasia type 1 (MEN1)-associated tumors.Molecular genetics of multiple endocrine neoplasia types 1 and 2.Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).Animal models of pituitary neoplasiaPriorities for improving the management of gastroenteropancreatic neuroendocrine tumors.Somatostatin stimulates menin gene expression by inhibiting protein kinase A.Multiple endocrine neoplasia type 1 (MEN1) as a cancer predisposition syndrome: clues into the mechanisms of MEN1-related carcinogenesis.Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.Critical role for hypothalamic mTOR activity in energy balance.Chromatin remodeling and bivalent histone modifications in embryonic stem cells.Translational research in neuroendocrine tumors: pitfalls and opportunities.Pathophysiology of Gastric NETs: Role of Gastrin and Menin.Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.A MEN1 pancreatic neuroendocrine tumour mouse model under temporal control.High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands.The future: genetics advances in MEN1 therapeutic approaches and management strategies.Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice.Glucocorticoids inhibited hypothalamic target of rapamycin in high fat diet-fed chicks.Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models.Characteristics of familial isolated pituitary adenomasPancreatic Neuroendocrine Tumor Producing Insulin and Vasopressin
P2860
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P2860
Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues
description
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
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im April 2004 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2004/04/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/04/01)
@nl
наукова стаття, опублікована у квітні 2004
@uk
مقالة علمية (نشرت في أبريل 2004)
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name
Conditional inactivation of th ...... l development of these tissues
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Conditional inactivation of th ...... l development of these tissues
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Conditional inactivation of th ...... l development of these tissues
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type
label
Conditional inactivation of th ...... l development of these tissues
@ast
Conditional inactivation of th ...... l development of these tissues
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Conditional inactivation of th ...... l development of these tissues
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prefLabel
Conditional inactivation of th ...... l development of these tissues
@ast
Conditional inactivation of th ...... l development of these tissues
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Conditional inactivation of th ...... l development of these tissues
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P2093
P2860
P50
P1476
Conditional inactivation of th ...... l development of these tissues
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P2093
Christine A Biondi
Graham F Kay
Michael G Gartside
Nicholas K Hayward
Paul Waring
P2860
P304
P356
10.1128/MCB.24.8.3125-3131.2004
P407
P577
2004-04-01T00:00:00Z