Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
about
Genetic characterization of the Drosophila birt-hogg-dubé syndrome geneCrystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancerFLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylationUBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor geneInactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localizationTumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signalingMetabolism of kidney cancer: from the lab to clinical practiceBirt-Hogg-Dube syndrome: clinicopathological features of the lungConserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingAmino acid management in cancerDiagnosis and management of BHD-associated kidney cancerThe metabolic basis of kidney cancerFolliculin regulates ampk-dependent autophagy and metabolic stress survivalExpression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis.Response and acquired resistance to everolimus in anaplastic thyroid cancerBeyond indigestion: emerging roles for lysosome-based signaling in human diseasemTOR signaling in tumorigenesisRegulation of mitochondrial oxidative metabolism by tumor suppressor FLCNThe folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell developmentExit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcriptionFolliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin.Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dubé syndrome: a double-blind placebo-controlled randomized split-face trial.Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression.MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma.Negative regulation of EGFR signalling by the human folliculin tumour suppressor proteinKidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathwayRecent updates in renal cell carcinomaThe genetic basis of kidney cancer: a metabolic diseaseNon-clear cell renal cancer: disease-based management and opportunities for targeted therapeutic approaches.Aerobic glycolysis: a novel target in kidney cancer.Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes.Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulationTargeted therapies for non-clear renal cell carcinoma.Renal cell tumour characteristics in patients with the Birt-Hogg-Dubé cancer susceptibility syndrome: a retrospective, multicentre study.Mouse models of inherited cancer syndromesFolliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells.Identification of intragenic deletions and duplication in the FLCN gene in Birt-Hogg-Dubé syndrome.
P2860
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P2860
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
description
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2009
@ast
im November 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/11/03)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/11/03)
@nl
наукова стаття, опублікована в листопаді 2009
@uk
name
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@ast
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@en
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@nl
type
label
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@ast
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@en
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@nl
prefLabel
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@ast
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@en
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@nl
P2093
P2860
P3181
P356
P1476
Homozygous loss of BHD causes ...... ctivation of mTORC1 and mTORC2
@en
P2093
Diana C Haines
Hisashi Hasumi
Laura S Schmidt
Mara E Klein
Maria J Merino
Rieko Ajima
Seung-Beom Hong
Terry P Yamaguchi
Vladimir A Valera
W Marston Linehan
P2860
P304
18722-18727
P3181
P356
10.1073/PNAS.0908853106
P407
P50
P577
2009-10-22T00:00:00Z