Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XLThe phosphorylation-dependent regulation of mitochondrial proteins in stress responsesBAD is a pro-survival factor prior to activation of its pro-apoptotic functionIBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activationProtein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosisAKT/PKB signaling: navigating downstreamPancreatic β Cell Mass DeathThe adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicityGLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cellsG-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD PhosphorylationBag1 is essential for differentiation and survival of hematopoietic and neuronal cells.Dual role of proapoptotic BAD in insulin secretion and beta cell survivalMechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell deathProtein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like regionReconstructing targetable pathways in lung cancer by integrating diverse omics dataInsulin signaling regulates mitochondrial function in pancreatic beta-cellsBAD detects coincidence of G2/M phase and growth factor deprivation to regulate apoptosis.Additive effects of cherlerythrine chloride combination with erlotinib in human non-small cell lung cancer cells.Specific epiblast loss and hypoblast impairment in cattle embryos sensitized to survival signalling by ubiquitous overexpression of the proapoptotic gene BADPharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.Interferon-gamma produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells.Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.Mitochondrial and postmitochondrial survival signaling in cancer.β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt.Macrophage Apoptosis and Efferocytosis in the Pathogenesis of AtherosclerosisDistinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.Ectopic over-expression of oncogene Pim-2 induce malignant transformation of nontumorous human liver cell line L02Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma developmentMesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpressionBad-deficient mice develop diffuse large B cell lymphoma.EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment.NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.Overexpression of Bcl-2-associated death inhibits A549 cell growth in vitro and in vivo.Decrease of Bcl-xL/Bcl-2-associated death promoter in hepatocellular carcinoma indicates poor prognosis.Polymerase synthesis and potential interference of a small-interfering RNA targeting hPim-2.Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L).A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?Autophagy: dual roles in life and death?
P2860
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P248
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P2860
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
description
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
scientific journal article
@en
vedecký článok (publikovaný 2002/11/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/11/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в листопаді 2002
@uk
مقالة علمية (نشرت في نوفمبر 2002)
@ar
name
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@ast
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@en
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@nl
type
label
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@ast
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@en
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@nl
prefLabel
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@ast
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@en
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@nl
P2093
P921
P3181
P1433
P1476
Survival factor-mediated BAD p ...... ndrial threshold for apoptosis
@en
P2093
Ann M Ranger
Chris W Cowan
James Fitzhugh Sturgill
Michael E Greenberg
Michael Z Lin
Pieter Dikkes
Sandeep Robert Datta
Stanley J Korsmeyer
P304
P3181
P356
10.1016/S1534-5807(02)00326-X
P407
P50
P577
2002-11-01T00:00:00Z