Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha
about
Trim24 targets endogenous p53 for degradationA Structural Basis for the Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor SuppressorsTranscription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemiaDistinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivationLoss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancerArterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alphaRhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activationThe polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.Estimating developmental states of tumors and normal tissues using a linear time-ordered model.TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damageTranscription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinomaLimiting the power of p53 through the ubiquitin proteasome pathway.Making sense of ubiquitin ligases that regulate p53.TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes.Predicting tissue specific transcription factor binding sites.Overexpression of TRIM24 is associated with the onset and progress of human hepatocellular carcinomaTRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).Striking differences between knockout and wild-type mice in global gene expression variabilityTripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibitionEpigenetic regulation by RARα maintains ligand-independent transcriptional activity.Autoantibodies to transcription intermediary factor 1 in dermatomyositis shed insight into the cancer-myositis connectionLoss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemiaClinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma.Identification of key genes in hepatocellular carcinoma and validation of the candidate gene, cdc25a, using gene set enrichment analysis, meta-analysis and cross-species comparison.T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy.TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC.Generation of mice with a conditional allele for Trim33.Vitamin A and retinoid signaling: genomic and nongenomic effects.Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma.Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).TRIMming p53 for ubiquitinationRARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma.A Transcriptomic Signature of Mouse Liver Progenitor CellsRadiation carcinogenesis: lessons from Chernobyl.Retinoids regulate stem cell differentiationBromodomains as therapeutic targets.Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations.Central role of RET in thyroid cancer.
P2860
Q24339423-E77CD4C8-86D8-4FC4-BC20-A54C1A701C94Q27674473-F9043D05-7CCB-44AE-8A91-AE045DF8667DQ28236628-60707CFB-73CE-47BD-8A38-0A5A7767334FQ28299905-25478FD7-4650-4711-BC73-2BE6DFD58537Q28505734-A3D39A66-0D28-4839-926A-F54702E26A78Q28511092-C598900F-FCED-4210-97B7-6E86E547E2A8Q28593417-5094D0DE-C4D6-46BD-8CD2-E790CB458554Q31162467-520F61FF-3B42-423D-9C69-254536CF30DCQ33486497-A53B7B65-219F-4558-8DA3-72A2B1015C1FQ33817598-C7999118-2292-4551-A42E-2BDAF0B25365Q33899861-40F0F9E3-4F1D-44E8-B0F8-C0E10479F33AQ34181413-A344059B-4205-4568-A53E-178681DC5354Q34342940-4F1DD94D-75E4-4DC8-9F6C-4EC7A76E786DQ34503497-62A0ED2D-DDF1-44D0-BD9B-99997F07A823Q34744808-B82A453B-B66F-4EDF-AD32-B0FF85043DCDQ35044479-F77C5DB4-DF69-4077-B38E-9758BD6358B0Q35084843-DA3C7066-D7CE-4647-BB9C-6216DE90E8BDQ35111028-AA76661F-5A43-498C-992E-989AA1AE931DQ35169000-24A83479-F232-458D-A2EF-705688F8179DQ35312100-53F888F5-2240-45E8-B792-066C70F2D8FEQ35633556-D9E65429-6007-4CF2-9BB6-62C05F11DA16Q35706669-1A99A8DF-EDF2-410D-B7C8-C67E8C12DB60Q36028489-61DFFB40-43D7-404C-842E-45DA4265F7DFQ36149634-9A0A2EF7-D8C2-417C-A58B-C2B5B56D52A9Q36520218-EA69FB30-60C6-42E3-9A72-147B45D2E974Q36563290-24EC73DB-EA35-4301-87E0-FAF05DDC947DQ36633583-17ADAF05-7876-4F32-8D69-CA49CFC25847Q36641420-5D30DB57-4CF6-4169-AC48-78EE2ABD0C9AQ36823455-49113794-17BD-40CF-821A-7F7D25A33244Q36920549-C998F12B-66E9-4A12-BF1F-CF31061FB7B1Q36972688-C8E54A36-8986-43AA-98B4-1F9C86A6C819Q37201722-98E522EA-74B1-45E8-83A0-96B94DC403B2Q37261753-FF2064D4-6681-4CFB-AE4A-0A57CF2C9D53Q37268965-6EFFE500-B84B-44E3-8DC6-C8CEBE449340Q37335215-502DFB75-17BD-4E0D-9D41-4CC0496422F8Q37643435-C998CC12-39DB-4EA1-A689-26B609319E45Q37788067-58715083-6F84-4C3B-BAA9-3448DBC215A3Q37935915-35271B66-5EBB-44AE-8BB0-37A60385209DQ37993420-B22C3A2E-469F-4EB5-B3B6-1B8DC4C8B0B7Q38167995-FD496B20-100C-4CFA-A763-E6AA57FACE33
P2860
Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha
description
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 2007
@ast
im Dezember 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/12/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/12/01)
@nl
наукова стаття, опублікована в грудні 2007
@uk
name
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@ast
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@en
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@nl
type
label
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@ast
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@en
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@nl
prefLabel
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@ast
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@en
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Loss of Trim24 (Tif1alpha) gen ...... o retinoic acid receptor alpha
@en
P2093
Benjamin Herquel
Florence Cammas
Johan Tisserand
Konstantin Khetchoumian
Manuel Mark
Régine Losson
Thierry Lerouge
P2860
P2888
P304
P3181
P356
10.1038/NG.2007.15
P407
P577
2007-12-01T00:00:00Z
P6179
1041435802