Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity
about
GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patientsCross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasisGuanylyl cyclase C as a biomarker in colorectal cancerGUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrityGuanylyl cyclase C signaling axis and colon cancer preventionAntiobesity pharmacotherapy: new drugs and emerging targetsLineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease.Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity.The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase GBile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis.Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis.Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrierThe uroguanylin system and human disease.PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesisThe paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancerPlecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC miceOccult tumor burden predicts disease recurrence in lymph node-negative colorectal cancerBacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics.A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.Occult tumor burden contributes to racial disparities in stage-specific colorectal cancer outcomes.Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer.Molecular staging individualizing cancer management.Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer.Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine.GUCY2C molecular staging personalizes colorectal cancer patient managementThe guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel diseaseSuppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases.GUCY2C: at the intersection of obesity and cancerPharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis.Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cellsGUCY2C ligand replacement to prevent colorectal cancer.Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis.Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9Bacterial genotoxins, gene methylation, and RNA interference: pointing to colorectal cancer as an infectious disease?Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer.Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancerIntestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21.
P2860
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P2860
Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity
description
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im August 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/08/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/08/01)
@nl
наукова стаття, опублікована в серпні 2007
@uk
مقالة علمية (نشرت في أغسطس 2007)
@ar
name
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@ast
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@en
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@nl
type
label
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@ast
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@en
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@nl
prefLabel
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@ast
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@en
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@nl
P2093
P3181
P1433
P1476
Guanylyl cyclase C suppresses ...... maintaining genomic integrity
@en
P2093
Alessandro Bombonati
Amy A Baran
Giovanni M Pitari
Juan P Palazzo
Linda D Siracusa
Stephanie Schulz
Terry M Hyslop
P304
P3181
P356
10.1053/J.GASTRO.2007.05.052
P407
P577
2007-06-02T00:00:00Z