Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice
about
The PICALM protein plays a key role in iron homeostasis and cell proliferationThe molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALMExpression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic miceCALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.Clathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells.Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis.FHL2 interacts with CALM and is highly expressed in acute erythroid leukemia.Systems genetic analysis of multivariate response to iron deficiency in mice.The role of CALM-AF10 gene fusion in acute leukemia.Identification and characterization of a novel murine allele of Tmprss6.A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l.A dynamic alternative splicing program regulates gene expression during terminal erythropoiesisAlzheimer's disease genetics: current knowledge and future challenges.Alzheimer's disease genetics: lessons to improve disease modelling.Turning CALM into excitement: AP180 and CALM in endocytosis and disease.The Role of PICALM in Alzheimer's Disease.Identification of novel Myc target genes with a potential role in lymphomagenesis.The CALM and CALM/AF10 interactor CATS is a marker for proliferation.Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network.Loss of Dynamin 2 GTPase function results in microcytic anaemia.The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12.CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes.The genetics of Alzheimer's disease
P2860
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P2860
Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2003
@ast
im Juli 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/07/08)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/08)
@nl
наукова стаття, опублікована в липні 2003
@uk
name
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@ast
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@en
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@nl
type
label
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@ast
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@en
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@nl
prefLabel
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@ast
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@en
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@nl
P2093
P2860
P356
P1476
Mutations in the clathrin-asse ...... ism abnormalities in fit1 mice
@en
P2093
Donald A. Carpenter
Erica L. Rowe
Eugene M. Rinchik
Mark D. Potter
Melissa D. Wall
Mitchell L. Klebig
P2860
P304
P356
10.1073/PNAS.1432634100
P407
P577
2003-07-08T00:00:00Z