The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation - Wikidata - awgldk - TriplyDB

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.wikidata.org/entity/Q28510062

about

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade Insulin receptor signaling in normal and insulin-resistant states Xenobiotic perturbation of ER stress and the unfolded protein response Endoplasmic reticulum stress and the related signaling networks in severe asthma Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases Molecular Pathogenesis of NASH Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program Fine tuning of the UPR by the ubiquitin ligases Siah1/2.Endoplasmic Reticulum Stress and Homeostasis in Reproductive Physiology and Pathology.BRD7 mediates hyperglycaemia-induced myocardial apoptosis via endoplasmic reticulum stress signalling pathway.Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway.Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K Regulation of basal cellular physiology by the homeostatic unfolded protein response Crohn's disease: NOD2, autophagy and ER stress converge.The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity.Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism Involvement of signaling molecules on na/h exchanger-1 activity in human monocytes.The critical role of GRP78 in physiologic and pathologic stress.NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis.Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease.Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival Systems biology of vaccination for seasonal influenza in humans.Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells.Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes.Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation.Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells.PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation Endoplasmic reticulum stress in liver disease.

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P2860

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.wikidata.org/entity/Q28510062

description

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2010

@ast

im April 2010 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2010/04/01)

@sk

vědecký článek publikovaný v roce 2010

@cs

wetenschappelijk artikel (gepubliceerd op 2010/04/01)

@nl

наукова стаття, опублікована у квітні 2010

@uk

مقالة علمية (نشرت في أبريل 2010)

@ar

name

The regulatory subunits of PI3 ...... ease its nuclear translocation

@ast

The regulatory subunits of PI3 ...... ease its nuclear translocation

@en

The regulatory subunits of PI3 ...... ease its nuclear translocation

@nl

type

label

The regulatory subunits of PI3 ...... ease its nuclear translocation

@ast

The regulatory subunits of PI3 ...... ease its nuclear translocation

@en

The regulatory subunits of PI3 ...... ease its nuclear translocation

@nl

prefLabel

The regulatory subunits of PI3 ...... ease its nuclear translocation

@ast

The regulatory subunits of PI3 ...... ease its nuclear translocation

@en

The regulatory subunits of PI3 ...... ease its nuclear translocation

@nl

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Nature Medicine

P1476

The regulatory subunits of PI3 ...... ease its nuclear translocation

@en

P2093

Allen Lu

http://www.w3.org/2001/XMLSchema#string

Cheng Sun

http://www.w3.org/2001/XMLSchema#string

Jason Chung

http://www.w3.org/2001/XMLSchema#string

Justin Lee

http://www.w3.org/2001/XMLSchema#string

Sang Won Park

http://www.w3.org/2001/XMLSchema#string

Umut Ozcan

http://www.w3.org/2001/XMLSchema#string

Yingjiang Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

Signal integration in the endoplasmic reticulum unfolded protein response

A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus.

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

Perk is essential for translational regulation and cell survival during the unfolded protein response

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

P2888

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429–437

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scholarly article

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254554

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P356

10.1038/NM.2099

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4

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16

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2010-04-01T00:00:00Z

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42611434

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1004091594

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20348926

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Phosphoinositide-3-kinase regulatory subunit 2

Phosphoinositide-3-kinase regulatory subunit 1

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3071012

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