Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)
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Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axesReduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug ResistanceCrystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 ÅTransporters at CNS barrier sites: obstacles or opportunities for drug delivery?Drug transporters in tissues and cells relevant to sexual transmission of HIV: Implications for drug deliveryFunctional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocationNucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitorsCharacterization of the rat Na+/nucleoside cotransporter 2 and transport of nucleoside-derived drugs using electrophysiological methodsBile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cellsComparative molecular biological analysis of membrane transport genes in organismsXenobiotic, bile acid, and cholesterol transporters: function and regulation.Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxiaSpecificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT.Efficiency of purine utilization by Helicobacter pylori: roles for adenosine deaminase and a NupC homolog.Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively.Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2.Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3.Current prodrug strategies via membrane transporters/receptors.Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes.Prognostic value of human equilibrative nucleoside transporter1 in pancreatic cancer receiving gemcitabin-based chemotherapy: a meta-analysis.First genome-wide association study in an Australian aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetesNucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy.Nucleoside transporters in chronic lymphocytic leukaemia.A conformationally mobile cysteine residue (Cys-561) modulates Na+ and H+ activation of human CNT3Challenges for the development of ribonucleoside analogues as inducers of error catastrophe.Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate.Enhancement of fludarabine sensitivity by all-trans-retinoic acid in chronic lymphocytic leukemia cells.Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells.Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.Ocular toxicity of fludarabine: a purine analogRenal nucleoside transporters: physiological and clinical implications.Concentrative nucleoside transporter 1 (hCNT1) promotes phenotypic changes relevant to tumor biology in a translocation-independent mannerConcentrative nucleoside transporters (CNTs) in epithelia: from absorption to cell signaling.The role of transporters in the toxicity of nucleoside and nucleotide analogs.Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity.Involvement of Multiple Transporters-mediated Transports in Mizoribine and Methotrexate Pharmacokinetics.Conserved glutamate residues Glu-343 and Glu-519 provide mechanistic insights into cation/nucleoside cotransport by human concentrative nucleoside transporter hCNT3
P2860
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P2860
Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)
description
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im Januar 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/01/26)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/01/26)
@nl
наукова стаття, опублікована в січні 2001
@uk
name
Molecular identification and c ...... idine nucleosides (system cib)
@ast
Molecular identification and c ...... idine nucleosides (system cib)
@en
Molecular identification and c ...... idine nucleosides (system cib)
@nl
type
label
Molecular identification and c ...... idine nucleosides (system cib)
@ast
Molecular identification and c ...... idine nucleosides (system cib)
@en
Molecular identification and c ...... idine nucleosides (system cib)
@nl
prefLabel
Molecular identification and c ...... idine nucleosides (system cib)
@ast
Molecular identification and c ...... idine nucleosides (system cib)
@en
Molecular identification and c ...... idine nucleosides (system cib)
@nl
P2093
P3181
P356
P1476
Molecular identification and c ...... idine nucleosides (system cib)
@en
P2093
C. E. Cass
D. A. Mowles
E. Karpinski
J. D. Young
K. M. Smith
M. W. Ritzel
P. Carpenter
R. G. Ritzel
P304
P3181
P356
10.1074/JBC.M007746200
P407
P577
2001-01-26T00:00:00Z