Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2
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Presenilins are essential for regulating neurotransmitter releaseAmyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunctionConditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegenerationMouse Genetic Models of Human Brain DisordersDynamic self-guiding analysis of Alzheimer's disease.Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortexPyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability.Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations.Familial dementia with frontotemporal features associated with M146V presenilin-1 mutationCharacterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine releaseConvergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegenerationAdult neurogenesis is functionally associated with AD-like neurodegenerationAdvances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis.Presenilin transgenic mice as models of Alzheimer's disease.Therapeutic options in Alzheimer's disease.Frontotemporal dementia-like phenotypes associated with presenilin-1 mutations.Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy.Ibuprofen rescues abnormalities in periodontal tissues in conditional presenilin 1 and presenilin 2 double knockout mice.An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.Presenilins in synaptic function and disease.Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression.Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms.p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide.Oxidative damage increased in presenilin1/presenilin2 conditional double knockout mice.Identification of gamma-secretase inhibitor potency determinants on presenilin.An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.Increased adult neurogenesis associated with reactive astrocytosis occurs prior to neuron loss in a mouse model of neurodegenerative disease.Dominant negative mechanism of Presenilin-1 mutations in FAD.The genes associated with early-onset Alzheimer's disease.Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness.Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice.
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P2860
Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2
description
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2004
@ast
im Mai 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/05/25)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/05/25)
@nl
наукова стаття, опублікована в травні 2004
@uk
name
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@ast
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@en
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@nl
type
label
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@ast
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@en
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@nl
prefLabel
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@ast
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@en
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@nl
P2093
P2860
P921
P3181
P356
P1476
Forebrain degeneration and ven ...... presenilin-1 and presenilin-2
@en
P2093
David Shrom
Huimin Wang
Jianlin Wang
Joe Z. Tsien
Ruiben Feng
Xuemei Zeng
P2860
P304
P3181
P356
10.1073/PNAS.0402733101
P407
P577
2004-05-25T00:00:00Z