Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.
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Synaptic function of nicastrin in hippocampal neuronsInactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunctionPartial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortexCREB binding protein is required for both short-term and long-term memory formation.Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathwayPresenilin/γ-secretase regulates neurexin processing at synapsesA new and reliable guide for studies of neuronal loss based on focal lesions and combinations of in vivo and in vitro approachesPresenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegenerationPresenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteinsThe keystone of Alzheimer pathogenesis might be sought in Aβ physiologyLoss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain.Presenilin-1 mutations and Alzheimer's disease.Amyloid-independent mechanisms in Alzheimer's disease pathogenesisPresenilins in synaptic function and disease.Biological function of Presenilin and its role in AD pathogenesisFunction and dysfunction of presenilinThe dark sides of amyloid in Alzheimer's disease pathogenesis.Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer's Disease Skin Fibroblasts.Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice.Increased adult neurogenesis associated with reactive astrocytosis occurs prior to neuron loss in a mouse model of neurodegenerative disease.Effects of Cu,Zn-superoxide dismutase on cell proliferation and neuroblast differentiation in the mouse dentate gyrus.Dominant negative mechanism of Presenilin-1 mutations in FAD.Big Data Analysis of Genes Associated With Neuropsychiatric Disorders in an Alzheimer's Disease Animal Model.
P2860
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P2860
Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Characterization of age-depend ...... nilin conditional mutant mice.
@ast
Characterization of age-depend ...... nilin conditional mutant mice.
@en
Characterization of age-depend ...... nilin conditional mutant mice.
@nl
type
label
Characterization of age-depend ...... nilin conditional mutant mice.
@ast
Characterization of age-depend ...... nilin conditional mutant mice.
@en
Characterization of age-depend ...... nilin conditional mutant mice.
@nl
prefLabel
Characterization of age-depend ...... nilin conditional mutant mice.
@ast
Characterization of age-depend ...... nilin conditional mutant mice.
@en
Characterization of age-depend ...... nilin conditional mutant mice.
@nl
P2093
P2860
P50
P1433
P1476
Characterization of age-depend ...... enilin conditional mutant mice
@en
P2093
Mary Wines-Samuelson
Raymond J Kelleher
Xinran Liu
P2860
P304
P356
10.1371/JOURNAL.PONE.0010195
P407
P577
2010-04-15T00:00:00Z