Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
about
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingCdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiationCumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephalyEstablishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedbackFunctional analysis of mutations in TGIF associated with holoprosencephaly.Hedgehog signaling and maintenance of homeostasis in the intestinal epitheliumSonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activityCdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in miceHedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteAll Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved MannerCrosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortexRegulation by miR181 family of the dependence receptor CDON tumor suppressive activity in neuroblastomaSonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothenedTGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathwayA sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathwayHaploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephalyGas1 extends the range of Hedgehog action by facilitating its signalingCortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDOGas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehogThe Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse developmentOcular abnormalities in mice lacking the immunoglobulin superfamily member CdoN-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblastsMechanisms that underlie co-variation of the brain and faceCdon promotes neural crest migration by regulating N-cadherin localization.A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development.Holoprosencephaly.Single median maxillary central incisor: new data and mutation review.Genetic and biochemical definition of the Hedgehog receptor.Ethanol itself is a holoprosencephaly-inducing teratogen.The molecular genetics of holoprosencephaly.A primary cilia-dependent etiology for midline facial disorders.Mechanism and evolution of cytosolic Hedgehog signal transductionCdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicleIdentification of transmembrane protein in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of CDON is involved in tumor cell growth and invasion.Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 functionKinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway.Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shapeOverlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors
P2860
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P2860
Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
description
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Mai 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/05/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/05/01)
@nl
наукова стаття, опублікована в травні 2006
@uk
مقالة علمية (نشرت في مايو 2006)
@ar
name
Cdo functions at multiple poin ...... model human holoprosencephaly
@ast
Cdo functions at multiple poin ...... model human holoprosencephaly
@en
Cdo functions at multiple poin ...... model human holoprosencephaly
@nl
type
label
Cdo functions at multiple poin ...... model human holoprosencephaly
@ast
Cdo functions at multiple poin ...... model human holoprosencephaly
@en
Cdo functions at multiple poin ...... model human holoprosencephaly
@nl
prefLabel
Cdo functions at multiple poin ...... model human holoprosencephaly
@ast
Cdo functions at multiple poin ...... model human holoprosencephaly
@en
Cdo functions at multiple poin ...... model human holoprosencephaly
@nl
P2093
P921
P3181
P1433
P1476
Cdo functions at multiple poin ...... model human holoprosencephaly
@en
P2093
Jong-Sun Kang
Min-Jeong Yi
Robert S Krauss
P304
P3181
P356
10.1016/J.DEVCEL.2006.04.005
P407
P577
2006-04-27T00:00:00Z