Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαThe schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapseAdaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomesCtip2-, Satb2-, Prox1-, and GAD65-Expressing Neurons in Rat Cultures: Preponderance of Single- and Double-Positive Cells, and Cell Type-Specific Expression of Neuron-Specific Gene Family Members, Nsg-1 (NEEP21) and Nsg-2 (P19)Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade.Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes.Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes.BLOC-1 deficiency causes alterations in amino acid profile and in phospholipid and adenosine metabolism in the postnatal mouse hippocampus.Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumoniaAGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus.Vesicles derived via AP-3-dependent recycling contribute to asynchronous release and influence information transferMeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models.The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.PreImplantation factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor.Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.Adaptor protein-3: A key player in RBL-2H3 mast cell mediator release.Presynaptic membrane retrieval and endosome biology: defining molecularly heterogeneous synaptic vesiclesThe Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the SynapseSynaptic vesicle generation from central nerve terminal endosomes.Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant miceThe Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway.Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes.VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3.UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes.Endocytic structures and synaptic vesicle recycling at a central synapse in awake rats.
P2860
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P2860
Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus
description
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im Januar 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/01/20)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/01/20)
@nl
наукова стаття, опублікована в січні 2010
@uk
مقالة علمية (نشرت في 20-1-2010)
@ar
name
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@ast
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@en
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@nl
type
label
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@ast
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@en
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@nl
prefLabel
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@ast
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@en
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@nl
P2093
P2860
P3181
P1476
Hermansky-Pudlak protein compl ...... n the striatum and hippocampus
@en
P2093
Jean-Francois Pare
LeeAnne McGaha
Sreenivasulu Chintala
Susan Jenkins
Yoland Smith
P2860
P304
P3181
P356
10.1523/JNEUROSCI.3400-09.2010
P407
P577
2010-01-20T00:00:00Z