The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαAssembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).Cinderella story: PI4P goes from precursor to key signaling moleculeAdaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomesCalcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes.Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes.Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus.MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.Association of the Hermansky-Pudlak syndrome type 4 (HPS4) gene variants with cognitive function in patients with schizophrenia and healthy subjects.Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation.Lysosome-related organelles: unusual compartments become mainstream.Dysfunction of the ubiquitin proteasome and ubiquitin-like systems in schizophrenia.Presynaptic membrane retrieval and endosome biology: defining molecularly heterogeneous synaptic vesiclesEmerging links between homeostatic synaptic plasticity and neurological disease.The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the SynapseThe schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice.Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus.Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks.Storage pool diseases illuminate platelet dense granule biogenesis.Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant miceThe Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.Sorting of the vesicular GABA transporter to functional vesicle pools by an atypical dileucine-like motif.Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes.VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3.BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia.Role of DISC1 interacting proteins in schizophrenia risk from genome-wide analysis of missense SNPs.Dynein binds and stimulates axonal motility of the endosome adaptor and NEEP21 family member, calcyon.Endocytic structures and synaptic vesicle recycling at a central synapse in awake rats.Effects of fingolimod administration in a genetic model of cognitive deficits.
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P2860
The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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The schizophrenia susceptibili ...... rom cell bodies to the synapse
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P2093
P2860
P921
P3181
P356
P1476
The schizophrenia susceptibili ...... rom cell bodies to the synapse
@en
P2093
Avanti Gokhale
Branch Craige
Jean-Francois Pare
Jennifer Larimore
Joshua D Lee
Karine Tornieri
Konrad Talbot
Pearl V Ryder
Stephanie A Zlatic
Victor Faundez
P2860
P304
P3181
P356
10.1091/MBC.E11-07-0592
P407
P577
2011-12-01T00:00:00Z