about
Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanismDNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survivalSynapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-CellsG-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT SignalingGenetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITORDeciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?BRAF activates and physically interacts with PAK to regulate cell motilityMyricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinomap21-Activated kinase 4 promotes prostate cancer progression through CREBPAK signalling during the development and progression of cancerInsulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in micePak1 as a novel therapeutic target for antihypertrophic treatment in the heartPhysical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinaseRandom versus directionally persistent cell migrationThe Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway ActivationThe Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions.Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cellsReceptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.Anti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest.The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cellsEssential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells.Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancersA Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.Republished: tracing PAKs from GI inflammation to cancerPotential compensation among group I PAK members in hindlimb ischemia and wound healing.FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.Regulation of Akt signaling activation by ubiquitination.Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets.Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.PAK1 as a therapeutic target.Group I Paks as therapeutic targets in NF2-deficient meningioma.Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.
P2860
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P2860
description
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im November 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/11/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/11/01)
@nl
наукова стаття, опублікована в листопаді 2008
@uk
مقالة علمية (نشرت في نوفمبر 2008)
@ar
name
Scaffolding function of PAK in the PDK1-Akt pathway
@ast
Scaffolding function of PAK in the PDK1-Akt pathway
@en
Scaffolding function of PAK in the PDK1-Akt pathway
@nl
type
label
Scaffolding function of PAK in the PDK1-Akt pathway
@ast
Scaffolding function of PAK in the PDK1-Akt pathway
@en
Scaffolding function of PAK in the PDK1-Akt pathway
@nl
prefLabel
Scaffolding function of PAK in the PDK1-Akt pathway
@ast
Scaffolding function of PAK in the PDK1-Akt pathway
@en
Scaffolding function of PAK in the PDK1-Akt pathway
@nl
P2093
P3181
P356
P1433
P1476
Scaffolding function of PAK in the PDK1-Akt pathway
@en
P2093
Chikako Kikuchi
Keisuke Onishi
Maiko Higuchi
Yukiko Gotoh
P2888
P304
P3181
P356
10.1038/NCB1795
P577
2008-11-01T00:00:00Z
P5875
P6179
1027897871