The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
about
PAX4 enhances beta-cell differentiation of human embryonic stem cellsTranslational implications of the β-cell epigenome in diabetes mellitusSpecific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survivalDevelopmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signalingPDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppressionHepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication.PAX Genes in Cancer; Friends or Foes?Pax genes in embryogenesis and oncogenesis.Inhibition of EGF signaling protects the diabetic retina from insulin-induced vascular leakage.Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences.MOPAT: a graph-based method to predict recurrent cis-regulatory modules from known motifs.Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors.PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet.Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest.Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity.
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P2860
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
description
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
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im Juni 2007 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2007/06/21)
@sk
vědecký článek publikovaný v roce 2007
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wetenschappelijk artikel (gepubliceerd op 2007/06/21)
@nl
наукова стаття, опублікована в червні 2007
@uk
مقالة علمية (نشرت في 21-6-2007)
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name
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@ast
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@en
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@nl
type
label
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@ast
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@en
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@nl
prefLabel
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@ast
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@en
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@nl
P2093
P2860
P356
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P1476
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210205
P407
P577
2007-01-29T00:00:00Z
P5875
P6179
1016583463