A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.
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Human epidermal growth factor receptor signaling in acute lung injurySubstance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent mannerDeciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signalingp21-Activated kinase inhibitors: a patent reviewMolecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitationsA Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in miceReduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibitionTransforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migrationArpin downregulation in breast cancer is associated with poor prognosis.Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cellsReceptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma.Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.Rac signaling in breast cancer: a tale of GEFs and GAPs.3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response.Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.A nanotopography approach for studying the structure-function relationships of cells and tissues.Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasisGroup I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways.Analysis of substrates of protein kinase C isoforms in human breast cells by the traceable kinase method.Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo.A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasisp-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPasesPak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signalingS6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1.PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells.A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitriesp21-activated kinase 1: PAK'ed with potential.Mouse models of PAK function.
P2860
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P2860
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@ast
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@en
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@nl
type
label
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@ast
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@en
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@nl
prefLabel
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@ast
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@en
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@nl
P2093
P2860
P356
P1433
P1476
A Rac-Pak signaling pathway is ...... reast epithelial cancer cells.
@en
P2093
L E Arias-Romero
S K Muthuswamy
P2860
P2888
P304
P356
10.1038/ONC.2010.318
P407
P577
2010-08-16T00:00:00Z
P5875
P6179
1004046155