Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2
about
NCLX is an essential component of mitochondrial Na+/Ca2+ exchangeHuman liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolismAn intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationshipA splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signalMechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesityCharacterization of recombinant adrenodoxin reductase homologue (Arh1p) from yeast. Implication in in vitro cytochrome p45011beta monooxygenase system.Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini.Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenaseMitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activityPhysiological role of the N-terminal processed P4501A1 targeted to mitochondria in erythromycin metabolism and reversal of erythromycin-mediated inhibition of mitochondrial protein synthesisEthanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytesAccumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone. A role in the metabolism of neuroactive drugsEvolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact pointsThe nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respirationThe efficiency of protein compartmentalization into the secretory pathway.Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase.Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicityTargeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.N-oxidation of aromatic amines by intracellular oxidases.A panoramic overview of mitochondria and mitochondrial redox biologyDrug-metabolizing cytochrome P450s in the brain.NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour prior to mitochondrial import.Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.Protein folding as a driving force for dual protein targeting in eukaryotesInteraction of α-synuclein with vesicles that mimic mitochondrial membranes.Single translation--dual destination: mechanisms of dual protein targeting in eukaryotes.Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates.Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells.Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity.Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases.Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease.Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principleBimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease.Mitochondrial translocation of amyloid precursor protein and its cleaved products: relevance to mitochondrial dysfunction in Alzheimer's disease.Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.
P2860
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P2860
Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2
description
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im November 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/11/03)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/11/03)
@nl
наукова стаття, опублікована в листопаді 1997
@uk
مقالة علمية (نشرت في 3-11-1997)
@ar
name
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@ast
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@en
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@nl
type
label
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@ast
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@en
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@nl
prefLabel
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@ast
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@en
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@nl
P2093
P2860
P356
P1476
Targeting of NH2-terminal-proc ...... hepatic mitochondrial P450MT2
@en
P2093
H. K. Anandatheerthavarada
J. Mullick
N. G. Avadhani
S. V. Bhagwat
P2860
P304
P356
10.1083/JCB.139.3.589
P407
P577
1997-11-03T00:00:00Z