Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone. A role in the metabolism of neuroactive drugs
about
Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolismCytochrome P450-mediated drug metabolism in the brainMitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activityEthanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytesEvolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact pointsMitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicityRegional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.Drug-metabolizing cytochrome P450s in the brain.Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity.Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principleBimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease.Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.Identification of mitochondrial cytochrome P450 induced in response to polycyclic aromatic hydrocarbons in the mummichog (Fundulus heteroclitus).Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting.β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment.
P2860
Q24310355-B6806CAA-0158-4478-982A-4585A312F667Q28397217-C7B93681-EB01-4668-A3F2-D0A8F089AACBQ28571662-0C15B388-ECCC-4F92-9E39-7D07CE5382A9Q28579862-81D0BF97-4467-4B89-AA4E-25646D751513Q28582715-FE0A4486-7235-40FC-A88D-14E25D08D043Q34042602-186BA3F2-C9E2-49F7-A1B5-FE24A479E3B1Q34134358-0C6F511B-4253-4D29-938E-5CDE69510379Q34152279-286EFE0D-3D08-474E-922B-720A026D85F9Q34396767-B1EC8B15-8977-4555-A611-BC1E146DD332Q35030396-CB9B587B-2504-4734-B48C-3672782659AEQ35482371-D2872FA8-3982-4227-AD41-CD61F6AC786EQ36473503-00C92651-9817-4C5A-9195-F23AC70C14FFQ36596353-F0CA099C-5E4B-49B0-BA2F-37D30CC9048DQ36812371-C9F3D26E-830A-4B32-8DD9-349AA7773F33Q37199118-0822C32F-85C0-40AD-BD42-6EF2E0CDB2E5Q37345082-7D4493B5-8FB1-4694-BAA7-5D59A97F4F26Q37683416-F54AADB2-0D79-434C-BB78-7094743E8573Q38921093-9E82633C-2423-4798-B00F-4A2AD62A8ADCQ41856709-B675227E-F59D-4549-BBA8-5481BBE93AA0Q42951784-C65A1176-299A-4B4B-9529-DA2A8AAC2510Q43372982-29963EE9-680A-4E35-A7E3-FAC46F8360D8
P2860
Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone. A role in the metabolism of neuroactive drugs
description
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im November 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/11/03)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/11/03)
@nl
наукова стаття, опублікована в листопаді 2000
@uk
name
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@ast
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@en
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@nl
type
label
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@ast
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@en
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@nl
prefLabel
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@ast
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@en
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@nl
P2093
P2860
P356
P1476
Accumulation of mitochondrial ...... etabolism of neuroactive drugs
@en
P2093
E. Boopathi
H. K. Anandatheerthavarada
J. K. Fang
N. G. Avadhani
S. V. Bhagwat
P2860
P304
34415–34423
P356
10.1074/JBC.M004431200
P407
P577
2000-11-03T00:00:00Z