Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
about
Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoformsTIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathwayS-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptideAtaxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaksGlutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activityNuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal deathOxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell lineThe role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotectionDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMAutophosphorylation and ATM activation: additional sites add to the complexity.Synaptic activity bidirectionally regulates a novel sequence-specific S-Q phosphoproteome in neuronsEZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.ATM is down-regulated by N-Myc-regulated microRNA-421.ROS-PIASĪ³ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors.Synaptic roles of cyclin-dependent kinase 5 & its implications in epilepsyThe phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenanceTargeting poly(ADP-ribose) polymerase activity for cancer therapy.ATM signalling and cancer.Neurological disorders associated with DNA strand-break processing enzymes.Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients.Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma.A positive role for c-Abl in Atm and Atr activation in DNA damage response.S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons.Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma.Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients.Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptorsThe impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiationPhosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neuronsp10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicityMLL1 is essential for the senescence-associated secretory phenotypeIdentification and cytoprotective function of a novel nestin isoform, Nes-S, in dorsal root ganglia neurons.The ATM signaling network in development and disease.Making a neuron: Cdk5 in embryonic and adult neurogenesis.Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis.Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer.Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors.ATM protein kinase: the linchpin of cellular defenses to stress.
P2860
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P2860
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
description
2009 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ„ÕæÖÕøÖÕ”ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
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@hyw
2009 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« ÖÕ„ÕæÖÕ¾Õ”ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
artĆculu cientĆficu espublizĆ”u en 2009
@ast
im Februar 2009 verƶffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedeckĆ½ ÄlĆ”nok (publikovanĆ½ 2009/02/01)
@sk
vÄdeckĆ½ ÄlĆ”nek publikovanĆ½ v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/02/01)
@nl
Š½Š°ŃŠŗŠ¾Š²Š° ŃŃŠ°ŃŃŃ, Š¾ŠæŃŠ±Š»ŃŠŗŠ¾Š²Š°Š½Š° Š² Š»ŃŃŠ¾Š¼Ń 2009
@uk
Ł
ŁŲ§ŁŲ© Ų¹ŁŁ
ŁŲ© (ŁŲ“Ų±ŲŖ ŁŁ ŁŲØŲ±Ų§ŁŲ± 2009)
@ar
name
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@ast
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@en
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@nl
type
label
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@ast
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@en
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@nl
prefLabel
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@ast
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@en
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@nl
P2093
P2860
P356
P1433
P1476
Phosphorylation of ATM by Cdk5 ...... g and regulates neuronal death
@en
P2093
P2860
P2888
P304
P356
10.1038/NCB1829
P577
2009-02-01T00:00:00Z
P5875
P6179
1027019466