Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
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TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathwayAcetylation of the pro-apoptotic factor, p53 in the hippocampus following cerebral ischemia and modulation by estrogenDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMUbiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5.Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression.High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5.Nestin as a regulator of Cdk5 in differentiating myoblasts.Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP.p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicityIdentification and cytoprotective function of a novel nestin isoform, Nes-S, in dorsal root ganglia neurons.4E-BP1, a multifactor regulated multifunctional proteinX-ray irradiation promotes apoptosis of hippocampal neurons through up-regulation of Cdk5 and p25N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells.Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial CellsNovel HIV-1 therapeutics through targeting altered host cell pathways.Cdk5: mediator of neuronal development, death and the response to DNA damage.Role of p53 in neurodegenerative diseases.Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development.Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit.Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses.CK1δ activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation.The Emerging Role of Cdk5 in CancerFlavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development.Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells.Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress.Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formationAnti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells.Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons.Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replication in vivo.Hard-metal (WC-Co) particles trigger a signaling cascade involving p38 MAPK, HIF-1α, HMOX1, and p53 activation in human PBMC.Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro.Regulation of TP53 Activity through PhosphorylationConverging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy.Parkinson disease-induced upregulation of apoptotic mediators could be attenuated in the skeletal muscle following chronic exercise training.Deciphering kinase-substrate relationships by analysis of domain-specific phosphorylation network.CDK5 phosphorylates TP53
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P2860
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
description
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Juli 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/07/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/07/01)
@nl
наукова стаття, опублікована в липні 2007
@uk
مقالة علمية (نشرت في يوليو 2007)
@ar
name
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@ast
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@en
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@nl
type
label
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@ast
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@en
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@nl
prefLabel
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@ast
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@en
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@nl
P2093
P921
P3181
P356
P1476
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
@en
P2093
Hea-Sook Kim
Jong-Hee Lee
Kyong-Tai Kim
Sung-Jin Lee
P304
P3181
P356
10.1242/JCS.03468
P407
P577
2007-07-01T00:00:00Z