Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy
about
Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeatFunctional gene-expression analysis shows involvement of schizophrenia-relevant pathways in patients with 22q11 deletion syndromeTbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular developmentLoss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndromeReduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium.An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull.Genetic modifiers of the physical malformations in velo-cardio-facial syndrome/DiGeorge syndrome.A molecular and genetic outline of cardiac morphogenesis.Molecular regulation of cardiomyocyte differentiation.Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteriesFrs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling.Tbx1 is necessary for palatal elongation and elevationIdentification of downstream genetic pathways of Tbx1 in the second heart field.Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesisGain of function of Tbx1 affects pharyngeal and heart development in the mouse.Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis.Cortical Development Requires Mesodermal Expression of Tbx1, a Gene Haploinsufficient in 22q11.2 Deletion Syndrome.An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time.22q11.2 Deletion Syndrome
P2860
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P2860
Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy
description
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im November 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/11/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/11/01)
@nl
наукова стаття, опублікована в листопаді 2006
@uk
مقالة علمية (نشرت في نوفمبر 2006)
@ar
name
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@ast
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@en
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@nl
type
label
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@ast
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@en
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@nl
prefLabel
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@ast
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@en
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@nl
P2093
P921
P3181
P356
P1476
Dissection of Tbx1 and Fgf int ...... suggests functional redundancy
@en
P2093
Alan Shanske
Alexei Bondarev
Bernice E. Morrow
Joseph Locker
Mark Lewandoski
Vimla S. Aggarwal
P304
P3181
P356
10.1093/HMG/DDL399
P577
2006-11-01T00:00:00Z