about
P688
Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutationIsolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 geneTbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in miceDiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron developmentTranscriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5aCooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formationThe del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesisDose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndromePrdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryoTbx1 regulates population, proliferation and cell fate determination of otic epithelial cellsTbx1 regulates proliferation and differentiation of multipotent heart progenitorsDistinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fatesRetinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal miceTbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathwaysTimed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansionTbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart fieldTbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear developmentTBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndromeAbsence of the vagus nerve in the stomach of Tbx1-/- mutant miceHes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndromeFgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutantsFull spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosagePartial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancyAsh2l interacts with Tbx1 and is required during early embryogenesisThe del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterningGreat vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in miceTBX1 is required for inner ear morphogenesisTbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndromeThe 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioningMesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract developmentIn vivo response to high-resolution variation of Tbx1 mRNA dosageTbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectodermTbx1 has a dual role in the morphogenesis of the cardiac outflow tractTbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery developmentA Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesisEarly thyroid development requires a Tbx1-Fgf8 pathwayProperties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryosIn vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea.
P921
Q24294577-875486BD-4BA6-42A3-9834-CADBC6C232D9Q24324759-0529BAE3-973A-44DD-B79A-4FBD58908098Q28204189-DB40C2C4-4B41-433B-A09D-60BE0D41060CQ28204282-306BFE55-E753-4E42-B0C0-1E70796FD3F7Q28246208-E441D6C5-1960-494A-99D9-181EA051501FQ28481519-2BAD97EF-0CCB-45AB-AB3B-8266558C7035Q28506318-221FAC80-F55A-4669-AFC6-391234255FFEQ28506844-09D834AC-7E19-487B-869B-31FD2F708D30Q28508893-CDF551C1-415F-4266-B8ED-1F6B4E8FCB89Q28509491-19F18B4E-0C61-48FA-B245-36FC15391825Q28509508-96DA7A19-3D52-4538-BF9B-645973875DFDQ28511103-E7FBB944-DA42-4102-8BD5-F3618F3E0185Q28511131-7680BEAA-2589-4592-A09F-F19709EE6018Q28511599-A241D242-8240-4076-A661-E689BA4B8FA5Q28511687-4A502257-BDB9-453A-815F-B29DEB7183CDQ28512256-5913C5A4-03F7-41C2-844C-F51B67B5C870Q28512364-B6FC8BD9-2509-46B7-B09D-5503EA1A3E94Q28512676-1F185BFE-2276-407A-92B5-C4E1D48FF055Q28512803-BD27263E-E0E0-45DE-9009-108A29DE6D70Q28513260-306FDB07-D6E6-44E0-8664-CC5132D39F39Q28513290-36AF0A0D-A0DC-4032-B140-7D75B8C3E549Q28513912-16F4717E-95B6-4622-B447-4E70E36C07FEQ28585095-98BCCA46-4AAE-48EF-9B54-C491C5838618Q28585923-38B3300A-F71A-4BE5-89AA-323B70932DC0Q28586089-7C9106A4-718D-4B56-904B-600E2CE86BA5Q28586170-CEE5C914-E252-4AEB-A1A4-B361FED88A13Q28586583-E0969AF1-36C6-40C8-B4D3-887F0C0E1D90Q28586874-79F70D24-D69B-4A29-91B3-02DAAABEF1C1Q28587238-B661BF67-5297-46A5-B1F5-3E9B0976309EQ28587462-B8D285D8-F5EB-4C6B-B69D-749963B0923FQ28587464-9E9624D3-0E76-4120-AC4F-6BAE33E163B1Q28587491-63A18F22-1DFD-4441-A635-881F3CBE18DFQ28587531-4BFAF5E7-B900-47C6-A3A5-F1B4B9C7E98AQ28588434-1526BFBB-0AE8-4018-AF8C-E5246C7892F2Q28588800-99D7F471-E147-4526-BCD7-58E1EFC3FCADQ28589109-E5EEC433-2773-45CD-8D10-B5F34378E0E0Q28589314-85021B23-2FB0-43E2-A0BE-7B1B513D4AC7Q28589620-13D486FC-0EAD-4C28-887C-AA7F4AA56493Q28589938-3E35BEC7-D8BD-4753-9F54-27696F4FEDD7Q28591405-11A851A1-F210-4CF0-BB55-24EFDE6A5FDA
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in T-box 1
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
T-box 1
@en
type
label
T-box 1
@en
altLabel
T-box protein 1
@en
T-box transcription factor TBX1
@en
Tbx1
@en
testis-specific T-box protein
@en
prefLabel
T-box 1
@en
P361
P637
P680
P682
P352
P279
P31
P352
P637
NP_001272401
NP_001272405
XP_006522041
XP_006522042
XP_017172414
P680
P681
P682
P702
P703
P705
ENSMUSP00000009241