Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
about
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammalsDisruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitroCDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairBRCA2 suppresses cell proliferation via stabilizing MAGE-D1Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeatsInteractions between human BRCA2 protein and the meiosis-specific recombinase DMC1BRCA1 and BRCA2 proteins: roles in health and diseaseAssociation of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risksDeficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joiningThe BRCA2 gene product functionally interacts with p53 and RAD51Role of BRCA gene dysfunction in breast and ovarian cancer predisposition.Distinct functions of BRCA1 and BRCA2 in double-strand break repairAre Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsBRCA2 acts as a RAD51 loader to facilitate telomere replication and cappingDSS1 is required for the stability of BRCA2Deletion of Ku86 causes early onset of senescence in miceM phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complexEpithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout miceThe Fanconi anaemia/BRCA pathwayAnalysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signalsUnraveling the mechanism of BRCA2 in homologous recombinationMinding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forksIdentification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouseCharacterizing a rat Brca2 knockout modelThymic model for examining BRCA2 expression and functionRAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis.A delayed chemically induced tumorigenesis in Brca2 mutant mice.A syngeneic variance library for functional annotation of human variation: application to BRCA2A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.Chromosome breaks and genomic instability.Comparison of prophylactic oophorectomy specimens from carriers and noncarriers of a BRCA1 or BRCA2 gene mutation. United Kingdom Coordinating Committee on Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group.The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination?Chromosome 8p alterations in sporadic and BRCA2 999del5 linked breast cancer.Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice.
P2860
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P2860
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
description
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 1997
@ast
im Dezember 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/12/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/12/01)
@nl
наукова стаття, опублікована в грудні 1997
@uk
name
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@ast
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@en
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@nl
type
label
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@ast
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@en
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@nl
prefLabel
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@ast
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@en
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@nl
P2093
P2860
P3181
P356
P1433
P1476
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
@en
P2093
D. Bertwistle
E. Grigorieva
G. M. Ross
V. L. Tybulewicz
P2860
P2888
P304
P3181
P356
10.1038/NG1297-423
P407
P577
1997-12-01T00:00:00Z
P5875
P6179
1032786877