Polycystic kidney disease prevented by transgenic RNA interference
about
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimeticsLoss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanismsMicroarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney diseaseBim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia.Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also BimThe RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis.Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.The renal H+, K+-ATPases as therapeutic targets.Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic.Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.Regulation of B-cell entry into the cell cycleModulation of vascular cell function by bim expression.Polycystins and cellular Ca2+ signaling.BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemiaApoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia.Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2-interacting mediator knock-out mice.
P2860
Q28469345-6C7C612C-DE47-4404-A763-EA6B78D08F45Q28511640-AE386CA1-EF52-4B6B-9FBB-BFA1D5EB9299Q33395144-3399DC15-E0D7-4FBC-A1ED-C85626F89B5CQ33737167-B69C8E28-D284-419D-8DD1-BC78B4A615C3Q33788708-16DF7C1A-6653-4BFC-B945-9B1F39855E02Q34450473-80A2B239-C02E-4B08-BDE0-9CD42B08BFACQ34718167-79018488-6A96-4922-A430-338EAF3C7434Q35075545-DDF73D2D-0D71-41ED-84D6-A40DD3938BCEQ36871972-0822E0C2-165F-45A0-9E15-8B74CDCB2617Q36945203-9131D877-B22E-4932-9690-1D5712B10EDBQ37179317-CE4FA5B3-14BC-478C-9EE8-F67F6928E367Q37256980-5E9A76BF-7E9B-4445-91AD-5795C66E8D72Q37323332-70D65FC0-81BA-4B84-AA27-D04EBB663668Q38053059-A3ABB9F9-00E7-4C26-AB93-D5967797FB9FQ38779981-634EEF52-2E47-477F-A688-C3891977C4F2Q39405994-9C6135E9-2E6C-4F4E-A780-C8A65EEE6D85Q40131183-1C5110AB-003E-4694-A53B-477517D78633Q47978809-CFC6B53B-CB2D-4898-9D4B-09584EC61F26
P2860
Polycystic kidney disease prevented by transgenic RNA interference
description
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Juli 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/07/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/07/01)
@nl
наукова стаття, опублікована в липні 2005
@uk
مقالة علمية (نشرت في يوليو 2005)
@ar
name
Polycystic kidney disease prevented by transgenic RNA interference
@ast
Polycystic kidney disease prevented by transgenic RNA interference
@en
Polycystic kidney disease prevented by transgenic RNA interference
@nl
type
label
Polycystic kidney disease prevented by transgenic RNA interference
@ast
Polycystic kidney disease prevented by transgenic RNA interference
@en
Polycystic kidney disease prevented by transgenic RNA interference
@nl
prefLabel
Polycystic kidney disease prevented by transgenic RNA interference
@ast
Polycystic kidney disease prevented by transgenic RNA interference
@en
Polycystic kidney disease prevented by transgenic RNA interference
@nl
P2860
P356
P1476
Polycystic kidney disease prevented by transgenic RNA interference
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.CDD.4401603
P577
2005-07-01T00:00:00Z