Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim - Wikidata - awgldk - TriplyDB

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

http://www.wikidata.org/entity/Q34450473

about

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.Epstein-Barr virus nuclear antigen 3A promotes cellular proliferation by repression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1.The essential role of evasion from cell death in cancer.Induced expression of nucleolin phosphorylation-deficient mutant confers dominant-negative effect on cell proliferation.The effect of BIM deletion polymorphism on intrinsic resistance and clinical outcome of cancer patient with kinase inhibitor therapy.BH3-only proteins in apoptosis at a glance Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs.The BCL-2 protein family, BH3-mimetics and cancer therapy.Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy.Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.Exosomal miR-10a derived from amniotic fluid stem cells preserves ovarian follicles after chemotherapy.A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice.Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis Evaluation of the BH3-only protein Puma as a direct Bak activator The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy.Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia.Non-Hodgkin's B-cell lymphoma: advances in molecular strategies targeting drug resistance.Apoptosis inducers in chronic lymphocytic leukemia.Epstein-Barr virus and Burkitt lymphoma.BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53.Tumor-Suppressor Functions of the TP53 Pathway.The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells.Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.Low carbohydrate diet prevents Mcl-1-mediated resistance to BH3-mimetics Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells.Selective IAP inhibition results in sensitization of unstimulated but not CD40-stimulated chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis.EBV and Apoptosis: The Viral Master Regulator of Cell Fate?p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells.

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P2860

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

http://www.wikidata.org/entity/Q34450473

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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type

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Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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prefLabel

Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

@ast

Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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Maximal killing of lymphoma ce ...... ts Puma and Noxa, but also Bim

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Cassandra J Vandenberg

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Clare L Scott

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Elisa S Jansen

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Ewa M Michalak

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Grant Dewson

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Jon M Haga

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Lina Happo

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P2860

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

The Bcl-2 apoptotic switch in cancer development and therapy

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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5256-5267

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scholarly article

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10.1182/BLOOD-2010-04-280818

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24

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116

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Andreas Strasser

Belinda Phipson

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2010-09-09T00:00:00Z

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46191458

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20829369

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3012543

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