Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
about
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family membersPresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyEssential roles for the FE65 amyloid precursor protein-interacting proteins in brain developmentMicroarray analysis of cultured rat hippocampal neurons treated with brain derived neurotrophic factorSelective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant miceSecreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathwayProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephaly.Human neocortical development: the importance of embryonic and early fetal events.Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling.Follicular fluid Aβ40 concentrations may be associated with ongoing pregnancy following in vitro fertilizationSoluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth.Peroxisomal multifunctional protein-2 deficiency causes motor deficits and glial lesions in the adult central nervous system.Notch signaling, brain development, and human disease.A genetic interaction between the APP and Dab1 genes influences brain development.Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairmentCortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signalingAccumulation of free oligosaccharides and tissue damage in cytosolic α-mannosidase (Man2c1)-deficient mice.Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.Functions of Aβ, sAPPα and sAPPβ : similarities and differences.Redundancy and divergence in the amyloid precursor protein family.Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells.Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal-Retzius cells.Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral CortexIdentification and characterization of presenilin-independent Notch signaling.Galpha12/Galpha13 deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices.Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures.Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling.Neuropathological and clinical phenotype of an Italian Alzheimer family with M239V mutation of presenilin 2 gene.The evolution of cortical development: the synapsid-diapsid divergence.DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes.Untangling cell tracks: Quantifying cell migration by time lapse image data analysis.Vitamin C Depletion in Prenatal Guinea Pigs as a Model of Lissencephaly Type II.Notch signaling and neuronal death in stroke.Malformations of cortical development
P2860
Q28504488-1E0D4A9B-4DB9-4475-9F47-038A941DE326Q28505078-47BC99D0-A32D-4E7A-A73F-4006949FE043Q28506956-37726B66-61F3-4A3A-B881-5855B4B92DDAQ28571356-5B33A1D3-9A65-41F7-8B35-CBEEEFA7CFFFQ28590682-A63F9219-25A9-4A96-8B56-0B1ACAF4AA91Q33813121-DB7E20A7-BA5B-49D7-AF76-CBF710D2B212Q34110227-8670D6E3-9D74-4000-B397-A45E88698DD2Q34228574-A2ECE411-2C27-4CBD-B4E6-BB9978EAE33BQ34327851-4168683C-A071-411F-B6EB-6E8277D4BBFCQ34565048-7D53F4A3-F9D4-473A-8C54-6FACAFB38237Q34603848-22EFF347-F2BE-4A3A-8D1F-93EA8A701D47Q35072706-93874D71-AC23-41A6-9BF0-D52B8925143DQ35088180-971A115B-176D-4790-9E02-C62132FE3513Q36092136-005036AF-3062-4578-A87E-527FD95B920EQ36506545-8FBEC5E1-00F2-4DF6-818F-31F6A6D09DC6Q36897576-1FF8B676-FF89-492E-91C4-BD8736EBD265Q36935667-FCC65F5A-F55B-4109-84C8-1EE6E319E866Q37683372-18673A8D-F3E2-43F8-AF19-B5403D6581F5Q37961473-31020F49-71EC-4BFD-B5F7-36AF94ACD76CQ37965817-58EBA571-BF8E-4597-A4EE-6E3F50A82EF9Q38109402-D862C5A1-02F1-4128-A0D7-B9C7149D9624Q38359652-2088985E-93EE-4634-9ACC-9ACA0D4201AEQ38637516-08622D19-318A-4912-B6C0-7E284DA515A2Q39285656-7A687F13-C724-4FB1-8DF0-2739DC87DDA9Q40760805-E29D4894-8B6B-4B47-AB9A-8231E6BAAC0FQ42522655-24B6F8A0-5F74-4B04-8986-80BF94BC3980Q43838097-033C74E6-2B41-4FFE-A711-0BB0A4962054Q44592816-4A4D3BA3-F36E-4B98-921F-B9A65B469A10Q44823227-801F8B2E-548D-4510-BA5A-4A78B6157A39Q47595678-EA8E22A9-DC8A-40D0-A52C-DA96DB4FEF96Q47599287-A8A4F7A0-442B-4B5F-B323-A67F8521D2CAQ47662094-0E7925CB-0AD7-453E-A0C3-58B63C1F0412Q48419865-763BBE93-1BEA-46AB-8E89-68F5CF44BFB1Q51759892-FC3BA66B-4F26-4522-ACD6-EBAA0424AFEAQ56232683-B5F6669A-515E-4DE0-88E2-FC57DDDC28D0
P2860
Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
description
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im Juli 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/07/15)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/07/15)
@nl
наукова стаття, опублікована в липні 1999
@uk
مقالة علمية (نشرت في 15-7-1999)
@ar
name
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@ast
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@en
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@nl
type
label
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@ast
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@en
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@nl
prefLabel
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@ast
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@en
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@nl
P2093
P3181
P1433
P1476
Presenilin-1 deficiency leads ...... to human type 2 lissencephaly
@en
P2093
B. De Strooper
D. Hartmann
P304
P3181
P356
10.1016/S0960-9822(99)80331-5
P407
P577
1999-07-15T00:00:00Z