Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
about
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulationPresenilin-1 regulates the expression of p62 to govern p62-dependent tau degradationPresenilin-mediated transmembrane cleavage is required for Notch signal transduction in DrosophilaFurin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activityNotch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cellsProtein O-fucosyltransferase 1 is an essential component of Notch signaling pathwaysDelta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sproutingNotch signaling maintains neural rosette polarityComplex regulation of γ-secretase: from obligatory to modulatory subunitsEndoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-proteinPresenilin clinical mutations can affect gamma-secretase activity by different mechanismsCombinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processingΓ-secretase components as predictors of breast cancer outcomeThe intracellular domain of CD44 promotes the fusion of macrophagesSynaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formationPresenilins regulate alphabeta T cell development by modulating TCR signalingNotch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somitesGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinSERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activityAlzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.The Gtx homeodomain transcription factor exerts neuroprotection using its homeodomain.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cellsgamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesNotch and the skeleton.Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis.Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoTransgenic models of Alzheimer's disease: learning from animalsDissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.Characterization of an atypical gamma-secretase complex from hematopoietic originConservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.Presenilin-dependent gamma-secretase activity modulates thymocyte development.Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.Role of glycosylation of Notch in developmentA presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activityRole of presenilins in neuronal calcium homeostasis
P2860
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P2860
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
description
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1999
@ast
im Oktober 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/10/12)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/10/12)
@nl
наукова стаття, опублікована в жовтні 1999
@uk
name
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@ast
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@en
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@nl
type
label
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@ast
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@en
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@nl
prefLabel
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@ast
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@en
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@nl
P2093
P2860
P50
P3181
P356
P1476
Presenilin 2 deficiency causes ...... ype of presenilin 1 deficiency
@en
P2093
A. Herreman
B. De Strooper
D. Hartmann
F. Van Leuven
H. Vanderstichele
K. Craessaerts
L. Serneels
P2860
P304
11872–11877
P3181
P356
10.1073/PNAS.96.21.11872
P407
P577
1999-10-12T00:00:00Z