Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling. - Wikidata - awgldk - TriplyDB

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling.

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling.

http://www.wikidata.org/entity/Q44592816

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Syndecan-syntenin-ALIX regulates the biogenesis of exosomes Proteoglycans in the central nervous system: role in development, neural repair, and Alzheimer's disease Protease regulation: the Yin and Yang of neural development and disease Syndecan-1 and Its Expanding List of Contacts Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins Notch inhibitors as a new tool in the war on cancer: a pathway to watch.Notch inhibition as a promising new approach to cancer therapy.Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer's disease model.Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements Male-specific association between a gamma-secretase polymorphism and premature coronary atherosclerosis.The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation.Papillomavirus infection requires gamma secretase.gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells.Pathological and physiological functions of presenilins.The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?Substrate specificity of gamma-secretase and other intramembrane proteases.gamma-Secretase: a multifaceted regulator of angiogenesis Trafficking of receptor tyrosine kinases to the nucleus The role of protease activity in ErbB biology.Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.The signaling mechanisms of syndecan heparan sulfate proteoglycans.Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK.The structure and function of Alzheimer's gamma secretase enzyme complex.Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.The many substrates of presenilin/γ-secretase.Regulated intramembrane proteolysis: signaling pathways and biological functions.γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.The physiology of the β-amyloid precursor protein intracellular domain AICD.Fell-Muir Lecture: Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour.Syntenin and syndecan in the biogenesis of exosomes.Nuclear translocation of intracellular domain of Protogenin by proteolytic cleavage.Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment.ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.The type III TGF-β receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase.

P2860

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P2860

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling.

http://www.wikidata.org/entity/Q44592816

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

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2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Syndecan 3 intramembrane prote ...... modulates cytosolic signaling.

@en

Syndecan 3 intramembrane prote ...... modulates cytosolic signaling.

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type

label

Syndecan 3 intramembrane prote ...... modulates cytosolic signaling.

@en

Syndecan 3 intramembrane prote ...... modulates cytosolic signaling.

@nl

prefLabel

Syndecan 3 intramembrane prote ...... modulates cytosolic signaling.

@en

Syndecan 3 intramembrane prote ...... modulates cytosolic signaling.

@nl

P1433

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P1476

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P1433

Journal of Biological Chemistry

P1476

Syndecan 3 intramembrane prote ...... modulates cytosolic signaling.

@en

P2093

Guido David

http://www.w3.org/2001/XMLSchema#string

Joachim G Schulz

http://www.w3.org/2001/XMLSchema#string

Joël Vandekerckhove

http://www.w3.org/2001/XMLSchema#string

Pascale Zimmermann

http://www.w3.org/2001/XMLSchema#string

Wim Annaert

http://www.w3.org/2001/XMLSchema#string

P2860

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

P304

48651-48657

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scholarly article

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10.1074/JBC.M308424200

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P407

P433

49

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P478

278

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Bart De Strooper

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2003-09-22T00:00:00Z

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P698

14504279

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P921