Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
about
Chromosomal instability and cancer: a complex relationship with therapeutic potentialThe role of aneuploidy in promoting and suppressing tumorsTranscription of the human cell cycle regulated BUB1B gene requires hStaf/ZNF143Mad2 overexpression promotes aneuploidy and tumorigenesis in miceManipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerConnecting the speckles: Splicing kinases and their role in tumorigenesis and treatment responseUnderstanding phenotypic variation in rodent models with germline Apc mutationsFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisDefining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 InhibitionDeficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ miceSumoylated BubR1 plays an important role in chromosome segregation and mitotic timing.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsGSK-3 inhibitors induce chromosome instability.The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.Mouse models of colorectal cancer.Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Chromosome missegregation causes colon cancer by APC loss of heterozygosity.Identification of FoxM1/Bub1b signaling pathway as a required component for growth and survival of rhabdomyosarcoma.How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse modelsThe chromosomal instability pathway in colon cancerA novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells.Illicit survival of cancer cells during polyploidization and depolyploidization.Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice.Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinomaPharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 functionAneuploidy and chromosomal instability in cancer: a jackpot to chaos.Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis.Losing balance: the origin and impact of aneuploidy in cancerAntagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability modelAtm is a negative regulator of intestinal neoplasia.Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Lipocalin 2 performs contrasting, location-dependent roles in APCmin tumor initiation and progression.Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer.Mitotic Origins of Chromosomal Instability in Colorectal Cancer.Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.Whole chromosome instability and cancer: a complex relationshipHigh rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.
P2860
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P2860
Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
description
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2005
@ast
im März 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/03/22)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/03/22)
@nl
наукова стаття, опублікована в березні 2005
@uk
name
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@ast
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@en
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@nl
type
label
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@ast
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@en
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@nl
prefLabel
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@ast
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@en
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@nl
P2093
P2860
P3181
P356
P1476
Colonic tumorigenesis in BubR1 ...... d enhanced genomic instability
@en
P2093
Chinthalapally V Rao
Malisetty V Swamy
Meena Jhanwar-Uniyal
Radma Mahmood
Tongyi Liu
Yang-Ming Yang
Yuqiang Fang
P2860
P304
P3181
P356
10.1073/PNAS.0407822102
P407
P50
P577
2005-03-14T00:00:00Z